Clinical Research Directory
Browse clinical research sites, groups, and studies.
Exploratory Study on the Correlation Between HRD Score and PARPi Efficacy Based on Chinese Ovarian Cancer Patients
Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Summary
This study plans to retrospectively include 470 initial surgical specimens from 470 patients with epithelial ovarian, fallopian tube or primary peritoneal cancers who were treated with PARPi maintenance therapy in the hospital from 2018.01 to 2024.01. All patients included would be scored by the proprietary HRD ADx-GSS® algorithm with the detecting results of the three genomic statuses including heterozygous omission (LOH), telomere allelic imbalance (TAI), and large-segment translocation (LST). Finally, the correlation between the HRD scores and the prognosis of Chinese ovarian cancer patients and the efficacy of using PARPi as maintenance treatment would be explored.
Official title: A Retrospective Study Exploring the Correlation Between HRD Score and PARPi Efficacy Based on Chinese Ovarian Cancer Patients
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
470
Start Date
2024-08-20
Completion Date
2026-07-07
Last Updated
2024-10-02
Healthy Volunteers
No
Interventions
Non-interventional
Non-interventional
Locations (1)
Sun Yat-sen memorial hospital
Guangzhou, Guangdong, China