Clinical Research Directory

Inclusion Criteria: 1. Established diagnosis of UC since at least 12 weeks prior to inclusion 2. Age ≥ 18 years 3. Any gender/sex 4. Active disease consistent with indication to start with Small molecules (defined as Mayo endoscopic score (MES) ≥ 1, partial Mayo score ≥ 3 (with at least rectal bleeding score of 1 and bowel movements score of 1) 5. No contraindications to endoscopy or confocal exam 6. Ability to understand and to comply with the study procedure and sign an informed consent form Exclusion Criteria: 1. Subjects with an endoscopic Mayo sub-score at baseline \<2; 2. Pregnancy 3. Subjects with any contraindication to any study procedure (included fluorescein allergy).