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An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Chronic Thyroid Eye Disease (TED)
Sponsor: Viridian Therapeutics, Inc.
Summary
This is a clinical trial assessing the efficacy, safety, and tolerability of an investigational drug, VRDN-003, in participants with chronic Thyroid Eye Disease (TED).
Official title: REVEAL-2 - A Phase 3, Randomized, Double-masked, Placebo-controlled, Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Chronic Thyroid Eye Disease (TED)
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
195
Start Date
2024-08-27
Completion Date
2026-12-15
Last Updated
2025-09-30
Healthy Volunteers
No
Conditions
Interventions
VRDN-003
VRDN-003 is an investigational, subcutaneously administered, humanized monoclonal antibody directed against the Insulin-like Growth Factor-1 receptor (IGF-1R).
Placebo
All participants will receive the same number of injections to maintain masking. Masking will be maintained by the use of placebo injections that appear identical to VRDN-003 injections.
Locations (37)
Scottsdale Clinical Trials
Scottsdale, Arizona, United States
Alliance Research Institute - Canoga Park
Canoga Park, California, United States
Marvel Clinical Research
Huntington Beach, California, United States
United Medical Research Institute
Inglewood, California, United States
Advancing Research International, LLC
Los Angeles, California, United States
Roski Eye Institute, Keck School of Medicine, USC
Los Angeles, California, United States
Alliance Research Institute - Lynwood
Lynwood, California, United States
A.P.J. Office
Newport Beach, California, United States
Byers Eye Institute at Stanford University
Palo Alto, California, United States
Pasadena Clinical Trials
Pasadena, California, United States
Senta Clinic
San Diego, California, United States
Ilumina Medical Research
Kissimmee, Florida, United States
Med-Care Research
Miami, Florida, United States
Hype Clinical Research LLC
Miami, Florida, United States
Anmed Health Services LLC
Miami, Florida, United States
Southern Clinical Research LLc
Miami, Florida, United States
Sarasota Retina Institute
Sarasota, Florida, United States
Agile Clinical Research Trials, LLC
Atlanta, Georgia, United States
Vision Medical Research
Orland Park, Illinois, United States
Massachusetts Eye and Ear
Boston, Massachusetts, United States
Opthalmic Consultants of Boston
East Weymouth, Massachusetts, United States
Fraser Eye Care Center
Fraser, Michigan, United States
Kahana Oculoplastic & Orbital Surgery
Livonia, Michigan, United States
University Health
Kansas City, Missouri, United States
S.L. Office
Las Vegas, Nevada, United States
Vector Clinical Trials
Sparks, Nevada, United States
Rutgers New Jersey Medical School
Newark, New Jersey, United States
Asheville Clinical Research
Asheville, North Carolina, United States
Duke Eye Center
Durham, North Carolina, United States
Scheie Eye Institute Penn Presbyterian
Philadelphia, Pennsylvania, United States
Wills Eye Hospital
Philadelphia, Pennsylvania, United States
Horizon Clinical Research Group
Cypress, Texas, United States
Baylor College of Medicine/Alkek Eye Center
Houston, Texas, United States
Gulf Coast Clinical Trials
Houston, Texas, United States
Neuro-Eye Clinical Trials
Houston, Texas, United States
University of Washington, Eye institute
Seattle, Washington, United States
West Virginia University Eye Institute
Morgantown, West Virginia, United States