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Longitudinal SV2A PET and MRI in Premanifest HD
Sponsor: Universitaire Ziekenhuizen KU Leuven
Summary
AIM: to compare the sensitivity of SV2A PET and volumetric MRI to detect longitudinal striatal changes in premanifest HD. DESIGN: The investigators will include late premanifest HD mutations carriers and matched healthy controls. All subjects will undergo a clinical examination, with comprehensive assessment of motor and non-motor symptoms, and imaging evaluation consisting of 18F-SynVesT-1 PET and volumetric MRI at baseline and after 2 years.
Official title: Longitudinal Imaging of Striatal Synaptic Density and Volume in People With Premanifest Huntington's Disease.
Key Details
Gender
All
Age Range
20 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2024-12-04
Completion Date
2028-12-31
Last Updated
2026-05-05
Healthy Volunteers
Yes
Conditions
Interventions
Diagnostic Test: 18F-SynVesT-1 PET
Positron Emission Tomography (PET) of synaptic vesicle protein 2A (SV2A) using the radioligand 18F-SynVesT-1.
Volumetric MRI
Magnetic resonance imaging of brain volume.
Locations (1)
University Hospitals Leuven
Leuven, Belgium