Clinical Research Directory
Browse clinical research sites, groups, and studies.
Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer
Sponsor: Case Comprehensive Cancer Center
Summary
The goal of this phase II single arm clinical study is to evaluate the effect of antibiotics (metronidazole) and oral chlorhexidine (CHX) in reducing the bacteria load within tumors of patients undergoing surgery for oral cancer.
Official title: A Phase II Single-arm Cohort Study Establishing the Effect of Antibiotic Treatment on Intratumoral Bacteria in Surgical Patients With Oral Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-03-11
Completion Date
2027-10-01
Last Updated
2026-03-05
Healthy Volunteers
No
Interventions
Metronidazole
Participants will receive metronidazole (500 mg t.i.d. x 10 days)
Chlorhexidine
Mouth rinse chlorhexidine (10 ml t.i.d. x 10 days)
Locations (1)
Case Comprehensive Cancer Center, Cleveland Clinic Foundation
Cleveland, Ohio, United States