Clinical Research Directory
Browse clinical research sites, groups, and studies.
Validating Digital Biomarkers to Detect Disease Activity and Disease Progression in Multiple Sclerosis
Sponsor: Amsterdam UMC, location VUmc
Summary
The Connect-MS is multicentre real-world observational cohort study wherin the outcomes of standard care digital monitoring of 700 patients with multiple sclerosis (including all subtypes) are recorded over a follow-up period of two years. Patients use the MS sherpa and NeuroKeys applications. Outcomes are related to the utilisation of digital biomarkers including the adherence to digital monitoring and the impact digital outcomes have on clinical decision making, the effect of digital monitoring on healthcare consumption, and the ability of these technological biomarkers to detect clinical outcomes on the short and long term. Most recorded variables are part of the standard care, however participants of this study are also subject to additional questionnaires regarding the consumption of healthcare and the influence of digital monitoring on decision making during clinical consultation.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
600
Start Date
2024-10-15
Completion Date
2028-01-01
Last Updated
2024-10-04
Healthy Volunteers
No
Conditions
Interventions
MS Sherpa
The MS Sherpa application is a CE-certified smartphone application (installed on the mobile phone of the patient) that collects digital biomarkers using tests (\~six minutes/test: self-monitoring questionnaires, smartphone 2-MWT, and a smartphone SDMT) once per week in the home environment of the patient.
Neurokeys
The NeuroKeys application is a CE-certified application (installed on the mobile phone of the patient) that passively and continuously monitors keystroke dynamics of everyday typing as a digital biomarker.
Locations (3)
Rijnstate Arnhem
Arnhem, Gelderland, Netherlands
Zuyderland Medical Center
Geleen, Limburg, Netherlands
Amsterdam UMC
Amsterdam, North Holland, Netherlands