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Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
Sponsor: Indiana University
Summary
Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2025-03-13
Completion Date
2029-10-30
Last Updated
2025-12-17
Healthy Volunteers
No
Conditions
Interventions
Therapist-Assisted Internet Cognitive-Behavioral Therapy for Depression
Good Days Ahead (MindStreet, Inc.)
Active Control
Depression education, symptom monitoring, and standard depression care
Locations (2)
Eskenazi Hospital
Indianapolis, Indiana, United States
IU Health Methodist Hospital
Indianapolis, Indiana, United States