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RECRUITING
NCT06627894
NA

Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

Sponsor: Indiana University

View on ClinicalTrials.gov

Summary

Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.

Key Details

Gender

All

Age Range

50 Years - Any

Study Type

INTERVENTIONAL

Enrollment

300

Start Date

2025-03-13

Completion Date

2029-10-30

Last Updated

2025-12-17

Healthy Volunteers

No

Interventions

BEHAVIORAL

Therapist-Assisted Internet Cognitive-Behavioral Therapy for Depression

Good Days Ahead (MindStreet, Inc.)

BEHAVIORAL

Active Control

Depression education, symptom monitoring, and standard depression care

Locations (2)

Eskenazi Hospital

Indianapolis, Indiana, United States

IU Health Methodist Hospital

Indianapolis, Indiana, United States