Clinical Research Directory

Inclusion Criteria: * Male or female over 18 years of age. * Patient, or if applicable, his or her guardian or legal representative, willing to give informed consent. * Clinically indicated for first intention total knee replacement. * Geographically stable and willing to return for all follow-up visits or, at a minimum, to complete the patient self-report score. Exclusion Criteria: * Vulnerable subject (as defined in ISO-14155) * Acute or chronic, local or systemic infection, * Muscular, ligamental, neurological, psychological or vascular deficits, * Bone destruction or poor bone quality likely to affect implant stability. * Any concomitant condition likely to affect implant integration or function, * Allergy or hypersensitivity to any of the materials used, * For devices in CoCr Mo (ISO 5832/4): renal and hepatic impairment, * Hip Knee Ankle (HKA) angle \< 165° or \> 195°, * Severe collateral ligament deficiency (requiring a more constrained prosthesis), * Major anatomical deformities, * Severe flexion contracture or severe recurvatum, * Revision of a partial or total knee prosthesis, * Non-extractible material (e.g., screw, plate, intramedullary nail, osteosynthesis material) which can create a conflict with any component of the prosthesis, * Distal and/or posterior and/or anterior femoral bone loss which exceeds the femoral component thickness, * Proximal tibial bone loss which exceeds the tibial component thickness (tibial tray + tibial insert), * Bone degradation requiring an anchoring stem for femoral component