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ENROLLING BY INVITATION
NCT06628180
NA

LIFU for Chronic Pain

Sponsor: Virginia Polytechnic Institute and State University

View on ClinicalTrials.gov

Summary

This research project is examining the effects of noninvasive brain stimulation on chronic pain. We believe this study will help us to better understand possible treatments for chronic pain patients. Subjects will undergo functional magnetic resonance imaging (fMRI) and a computed tomography (CT) scan, which is a way to take pictures of the brain and skull. Subjects will receive noninvasive brain stimulation using low-intensity focused ultrasound (LIFU) sound waves, to temporarily change brain activity. Subjects will undergo pain testing using a small device that will increase the temperature of their skin and will rate this pain. Brain signals (EEG), heart rate and rhythm, blood pressure, respiration rate, and skin moisture will be monitored. Subjects will complete behavioral questionnaires. Each study session is expected to take 1.5-3 hours. Total participation takes 10 weeks.

Official title: Investigation of Accelerated LIFU: Towards Therapeutic Use for Chronic Pain

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

80

Start Date

2025-01-30

Completion Date

2026-10

Last Updated

2026-03-31

Healthy Volunteers

No

Conditions

Interventions

DEVICE

LIFU

Application of low-intensity focused ultrasound for neuromodulation

DEVICE

Sham LIFU

Sham application of LIFU - will appear the same to participants.

Locations (1)

Fralin Biomedical Research Institute at VTC

Roanoke, Virginia, United States