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LIFU for Chronic Pain
Sponsor: Virginia Polytechnic Institute and State University
Summary
This research project is examining the effects of noninvasive brain stimulation on chronic pain. We believe this study will help us to better understand possible treatments for chronic pain patients. Subjects will undergo functional magnetic resonance imaging (fMRI) and a computed tomography (CT) scan, which is a way to take pictures of the brain and skull. Subjects will receive noninvasive brain stimulation using low-intensity focused ultrasound (LIFU) sound waves, to temporarily change brain activity. Subjects will undergo pain testing using a small device that will increase the temperature of their skin and will rate this pain. Brain signals (EEG), heart rate and rhythm, blood pressure, respiration rate, and skin moisture will be monitored. Subjects will complete behavioral questionnaires. Each study session is expected to take 1.5-3 hours. Total participation takes 10 weeks.
Official title: Investigation of Accelerated LIFU: Towards Therapeutic Use for Chronic Pain
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2025-01-30
Completion Date
2026-10
Last Updated
2026-03-31
Healthy Volunteers
No
Conditions
Interventions
LIFU
Application of low-intensity focused ultrasound for neuromodulation
Sham LIFU
Sham application of LIFU - will appear the same to participants.
Locations (1)
Fralin Biomedical Research Institute at VTC
Roanoke, Virginia, United States