Clinical Research Directory

Inclusion Criteria: * Agree to participate in the study * 32-42 years old * Having at least one previous embryo implantation failure * History of low Embryo quality at day3 or day5 (according to Veeck's and Gardner's Criteria) * No major uterine or ovarian abnormalities * BMI level 18-25kg/m2 Exclusion Criteria: * Ovarian endometriosis with Chocolate cysts (AFS type 3 and 4) * Patients who have taken different supplements such as coenzyme Q10, vitamin E, carnitine,niacin, nicotinamide, or other vitamin B3-related etc. within the previous month * Any medical contraindication of oocyte retrieval or subsequent procedures * Couples where the husband presents with severe sperm abnormalities * Couples where the husband presents \<5 million/mL motile sperm * Uterine structural anomalies * Polycystic ovaries * Premature ovarian failure * Individuals who need regular medication to treat chronic diseases such as diabetes, hypertension, gout, hyperuricemia, etc. * Individuals who need drug treatment for any mental illness such as epilepsy and depression. * Individuals who suffer from infectious diseases such as hepatitis B, active tuberculosis, AIDS, etc. * Cancer patients or receiving chemo/radiotherapy treatment within the past 3 years.