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Intelligence and Neurodevelopmental Disorders After Prenatal Exposure to General Anaesthesia
Sponsor: Universitaire Ziekenhuizen KU Leuven
Summary
Every year in the European Union, thousands of babies are exposed to anaesthesia before they are born because their mothers need surgery during pregnancy. While these surgeries are necessary, there is a concern that the anaesthesia might affect the baby's brain development. However, there isn't enough research to know for sure how this exposure might impact the child's intelligence or behavior later in life. The goal of this cohort study is to compare the intelligence and neurodevelopmental outcome of children prenatally exposed to general anaesthesia for maternal abdominal surgery with those of unexposed children and with those of children prenatally exposed to maternal inflammation.
Official title: Intelligence and Neurodevelopmental Disorders After Prenatal Exposure to General Anaesthesia for Maternal Abdominal Surgery: A Propensity Score Weighted Multicentre Clinical Bidirectional Cohort Study.
Key Details
Gender
All
Age Range
2 Years - 27 Years
Study Type
OBSERVATIONAL
Enrollment
192
Start Date
2024-10-14
Completion Date
2027-12
Last Updated
2026-01-09
Healthy Volunteers
Yes
Conditions
Interventions
Age-appropriate Wechsler Intelligence Test
2.5-6 years: Wechsler Preschool and Primary Scale of Intelligence for children (WPPSI IV) 7-16 years: Wechsler Intelligence Scale for Children (WISC V) \>17 years: Wechsler Adult Intelligence Scale (WAIS IV)
Disruptive Behavior Disorders Rating Scale
Dutch version of the Disruptive Behavior Disorders Rating Scale
Social Responsiveness Scale
3-18 years: social responsiveness scale 2 (SRS-2) \>19 years: Social Responsiveness Scale - Adult version (SRS-A)
Locations (3)
Imeldaziekenhuis
Bonheiden, Antwerpen, Belgium
UZ Leuven
Leuven, Vlaams-Brabant, Belgium
AZ Delta
Roeselare, West-Flanders, Belgium