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Profile and Regulatory Network of Exercise in Improving Metabolic Phenotypes of Patients With Prediabetes
Sponsor: Shanghai Zhongshan Hospital
Summary
This study is a single-arm, self-control, single-center study to investigate the molecular mechanism under exercise improving metabolism of patients with prediabetes. 40 overweight/obese patients with prediabetes will be recruited in this study and instructed to participate in an 8-week exercise program. We aim to investigate 1) the changes of clinical phenotypes such as body weight, body fat, laboratory values, and resting energy expenditure before and after exercise 2) the changes of peripheral blood mononuclear cell by single cell sequencing 3) search for potential biomarkers of exercise in improving metabolism through multi-omics integrated analysis of single-cell transcriptome, phenomics, metabolomics, etc.
Key Details
Gender
All
Age Range
19 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2024-10-12
Completion Date
2027-10-09
Last Updated
2026-03-12
Healthy Volunteers
No
Conditions
Interventions
exercise intervention
Patients will participate in an 8-week supervised aerobic exercise program, the intensity was set at the moderate to vigorous intensity (≥150mins/week exercise on the treadmill).
Locations (1)
Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, China