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Auditory Research in Children Living With HIV Exposure-uninfected (ARCHIVE)
Sponsor: San Diego State University
Summary
To evaluate the association of in utero antiretroviral therapy (ART) exposure and hearing abilities of children who were perinatally HIV-exposed, but HIV-free, stratified by timing of maternal ART initiation.
Key Details
Gender
All
Age Range
7 Years - 9 Years
Study Type
INTERVENTIONAL
Enrollment
35
Start Date
2026-01-01
Completion Date
2030-03-31
Last Updated
2025-05-01
Healthy Volunteers
Yes
Conditions
Interventions
Dichotic Interaural Intensity Difference (DIID) Training
A total of five trials will be presented in a sequence and there will be 10 sequences per training session. Each of the 25 consonant-vowel-consonant words or digits 1 through 10 (excluding 7) will be presented to each ear during the session. The pairs will be randomized every time, and a word will never be paired with itself. After a sequence is completed, the difficulty of the task will be adjusted, in real time, based on performance on the prior task. If the child scored 4 or 5 of 5 correct in the poorer ear, then the IID will be decreased by 2 dB making the task more difficult. If the child scores 0, 1, or 2 of 5 correct, then the IID will be increased by 2 dB making the task easier. Last, if the child scores 3 of 5 correct, then the IID will remain unchanged for the next sequence.