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RECRUITING
NCT06637332
PHASE4

Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia

Sponsor: Todd C. Lee MD MPH FIDSA

View on ClinicalTrials.gov

Summary

This is an open label randomized controlled trial for patients with methicillin resistant S. aureus (MRSA) bloodstream infection which will directly compare the two most commonly used therapies, vancomycin and daptomycin. This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119)

Official title: DAPTO-SNAP: Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

300

Start Date

2024-11-14

Completion Date

2027-11

Last Updated

2026-02-25

Healthy Volunteers

No

Interventions

DRUG

Daptomycin for Injection

Daptomycin given by injection at a dose determined by the treating team but not to be less than 6mg/kg

DRUG

Vancomycin (IV)

Vancomycin by injection to be given at a dose selected by the treating team to achieve a desired trough level or AUC-based target, as determined by local standards of care

Locations (14)

Concord Repatriation and General Hospital

Concord, New South Wales, Australia

John Hunter Hospital

Newcastle, New South Wales, Australia

Westmead Hospital

Westmead, New South Wales, Australia

Royal Brisbane and Women's Hospital

Herston, Queensland, Australia

Flinders Medical Centre

Bedford Park, South Australia, Australia

Box Hill Hospital

Box Hill, Victoria, Australia

Monash Medical Campus (Monash Medical Centre + Jesse McPherson Private Hospital)

Clayton, Victoria, Australia

Royal Melbourne Hospital

Parkville, Victoria, Australia

Fiona Stanley Hospital

Murdoch, Western Australia, Australia

Royal Perth Hospital

Perth, Western Australia, Australia

Fraser Health Authority (Surrey Memorial Hospital)

Surrey, British Columbia, Canada

Newfoundland Health Services (Health Sciences Centre and St. Clare's Mercy Hospital)

St. John's, Newfoundland and Labrador, Canada

Hamilton Health Sciences (Hamilton General Hospital and Juravinski Hospital)

Hamilton, Ontario, Canada

McGill University Health Centre (Royal Victoria Hospital and Montreal General Hospital)

Montreal, Quebec, Canada