Clinical Research Directory
Browse clinical research sites, groups, and studies.
PrEP Readiness Interventions for Sustained Motivation (PRISM)
Sponsor: Florida International University
Summary
This is a hybrid type I, factorial randomized controlled trial to test the comparative and combined effectiveness of contingency management (CM) alone or CM with motivational interviewing (MI) for optimizing entry or re-entry into the PrEP care continuum. A total of 400 participants will be randomized to CM (n = 200) or MI+CM (n = 200), all delivered via Telehealth. Monthly follow-up assessments will be completed over 12 months to examine differential effectiveness for the primary outcome - filling a PrEP prescription (verified using a digital photo or detectable tenofovir diphosphate). Secondary outcomes will include: self-reported PrEP clinical evaluation by a PrEP provider; self-reported meth and other substance use severity (ASSIST), and self-reported receptive and insertive condomless anal sex (CAS).
Official title: Optimizing HIV Prevention for Highly Vulnerable Methamphetamine-using Sexual Minority Men
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2025-01-28
Completion Date
2028-04-30
Last Updated
2026-02-18
Healthy Volunteers
No
Conditions
Interventions
Motivational Interviewing (MI)
This telehealth MI intervention seeks to increase intrinsic motivation and self-efficacy for starting or restarting pre-exposure prophylaxis (PrEP) in session one. Session two focuses on concomitant risk behaviors such as substance use and CAS.
Contingency Management (CM)
Provides incentives for initiating PrEP care ($50) and filling a PrEP prescription ($50) in the three months following randomization.
Locations (2)
Florida International University Stempel College of Public Health and Social Work
Miami, Florida, United States
Florida International University
Miami, Florida, United States