Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of Different Programs to Help ALL Patients With Taking Maintenance Medicine at Home
Sponsor: Children's Oncology Group
Summary
This clinical trial tests different programs to help patients with acute lymphoblastic leukemia (ALL) remember to take their medications during maintenance therapy at home. One problem with ALL maintenance treatment is remembering to take medicines at home like patients are supposed to. In maintenance, a medicine called 6-mercaptopurine or "6MP" is taken by mouth every day at home. In this study, 6MP prescriptions are filled into a special medication bottle called MEMS® which is fitted with a special cap called TrackCap™ that electronically records when the medication bottle is opened. Researchers are trying a new program to help patients be better at taking their 6MP like they're supposed to. This new program may help patients to remember to take their 6MP medication.
Official title: Risk-Based 6MP Adherence Enhancement Strategies in Children, Adolescent and Young Adults With ALL - A Pilot Study
Key Details
Gender
All
Age Range
10 Years - 25 Years
Study Type
INTERVENTIONAL
Enrollment
64
Start Date
2024-12-04
Completion Date
2027-03-03
Last Updated
2026-10-05
Healthy Volunteers
No
Interventions
Biospecimen Collection
Undergo blood sample collection
Compliance Monitoring
Receive DST
Compliance Monitoring
Healthcare provider reviews DST response rates with the patient and any challenges they are having with 6MP adherence every 4 weeks at clinic visits
Health Promotion and Education
Receive customized printed medication schedules
Informational Intervention
Receive Patient Supply Kit
Media Intervention
View MIPE program videos
Media Intervention
Review booster MIPE videos
Medical Device Usage and Evaluation
Use MEMS® with TrackCap™
Mercaptopurine
Given PO
Questionnaire Administration
Ancillary studies
Telephone-Based Intervention
Receive automated customized electronic reminders via smartphone
Telephone-Based Intervention
Receive additional automated reminders
Telephone-Based Intervention
Manually activate daily smartphone reminders with successive alerts (using the "snooze" function)
Telephone-Based Intervention
Receive electronic reminders with successive alerts (using the "snooze" function)
Training and Education
Undergo training for prompting and supervising 6MP
Locations (27)
Children's Hospital of Alabama
Birmingham, Alabama, United States
Arkansas Children's Hospital
Little Rock, Arkansas, United States
Kaiser Permanente-Oakland
Oakland, California, United States
Alfred I duPont Hospital for Children
Wilmington, Delaware, United States
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, United States
Nemours Children's Clinic-Jacksonville
Jacksonville, Florida, United States
AdventHealth Orlando
Orlando, Florida, United States
Nemours Children's Hospital
Orlando, Florida, United States
Riley Hospital for Children
Indianapolis, Indiana, United States
Eastern Maine Medical Center
Bangor, Maine, United States
Sinai Hospital of Baltimore
Baltimore, Maryland, United States
C S Mott Children's Hospital
Ann Arbor, Michigan, United States
University Medical Center of Southern Nevada
Las Vegas, Nevada, United States
Sunrise Hospital and Medical Center
Las Vegas, Nevada, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada, United States
Summerlin Hospital Medical Center
Las Vegas, Nevada, United States
Renown Regional Medical Center
Reno, Nevada, United States
Roswell Park Cancer Institute
Buffalo, New York, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Rhode Island Hospital
Providence, Rhode Island, United States
Prisma Health Richland Hospital
Columbia, South Carolina, United States
Dell Children's Medical Center of Central Texas
Austin, Texas, United States
Methodist Children's Hospital of South Texas
San Antonio, Texas, United States
Inova Fairfax Hospital
Falls Church, Virginia, United States
Children's Hospital of The King's Daughters
Norfolk, Virginia, United States
Madigan Army Medical Center
Tacoma, Washington, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, United States