Clinical Research Directory

Inclusion Criteria: 1. Healthy Asians; 2. 20-55 years old; 3. Having mandibular third molars that are inappropriately erupted and need to be extracted due to caries, orthodontic reasons and/or periodontal disease; Exclusion Criteria: 1. Underlying diseases: diabetes, cardiovascular disease, coagulation disorder, osteoporosis, hypertension, neurological disease, psychological disorder, tumor, systemic infection or cyst at the extraction site; 2. Women who are preparing for pregnancy, pregnant or breastfeeding; 3. Medication history: use of analgesics, anti-inflammatory drugs and/or antibacterial drugs 2 weeks before tooth extraction, need for systemic medication other than acetaminophen after surgery, allergy to acetaminophen, use of anticoagulants, bisphosphonates; 4. Bad habits, such as addicted to smoking, drinking, etc.; 5. Volunteers who have recently participated in other clinical trials;