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Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation
Sponsor: IRCCS San Camillo, Venezia, Italy
Summary
The study aims to investigate neural correlate of Mild Cognitive Impairment (MCI) in Parkinson's disease (PD) and to identify a link between functional impairment (in both cognitive and motor domains) and electrophysiological cortical sing of MCI in PD. A sample of 42 subjects will be divide into three subgroup: healthy control, PD with MCI (PD-MCI) and PD without MCI (PD-ctrl). Those subjects will undergo a specific neuropsychological evaluation and, to measure the electro-cortical activity, high-density electroencephalography (hdEEG) will be record during both resting state and cognitive tasks. Furthermore, hdEEG data will be combine with structural magnetic resonance to obtain information about network connectivity.
Key Details
Gender
All
Age Range
50 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
42
Start Date
2023-06-18
Completion Date
2025-05
Last Updated
2024-10-15
Healthy Volunteers
Yes
Interventions
Hd-EEG
Subjects undergo a clinical and neuropsychological assesment, then a Hd-EEG both during resting state and execution of tasks, and structural Magnetic Resonance Imaging
Locations (1)
IRCCS San Camillo S.R.L
Lido, Italy, Italy