Clinical Research Directory

Inclusion Criteria: 1. Adult patients of age 18 or older with clinical and imaging evidence of venous malformations and/or venous insufficiency of the periphery 2. Lesions no deeper than 4.0cm from the skin surface 3. Lesions appropriate for and patient amenable to HIFU therapy of targeted vascular lesion/structure as determined by the principal operator and investigator 4. Ability to provide treatment consent for Sonablate HIFU energy delivery 5. Ability and willingness to remain compliant with recommended post-op follow-up Exclusion Criteria: 1. Patient unable or unwilling to provide consent 2. Patient unable or unwilling to undergo HIFU energy delivery 3. Patient with vascular lesions involving the central nervous system, face, head, and neck, genitalia, visceral or internal organs 4. Patient with known vasculitis or other inflammatory vasculopathies 5. Patients with active or prior history of DVT or PE 6. Any lesion deemed unsafe by the treating surgeon or PI of the study for HIFU at the time of treatment based on clinical assessment, ultrasonographic features and/or probe positioning limitations 7. Subject who has vascular tissue targets lying \<1cm from sensitive structures or large vessels 8. Women who are pregnant or planning to become pregnant prior to procedure or within the 30-day study period, or nursing 9. Vulnerable patients 10. Subject with vessels \>6 mm in diameter within the vascular tissue target