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A Pragmatic Trial Comparing Empagliflozin and Dapagliflozin Through Cluster Randomization Embedded in the Electronic Health Record
Sponsor: Herlev and Gentofte Hospital
Summary
The aim of this clinical trial is investigate the comparative effectiveness of empagliflozin and dapagliflozin for the treatment of diabetes, chronic kidney disease, and heart failure. Patients who are prescribed either empagliflozin or dapagliflozin, as part of daily clinical practice at the participating sites, will be included in the study. Treatment will be randomized automatically through the electronic health record software in clusters defined by time of day. https://www.appletreestudy.com
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
17200
Start Date
2024-10-10
Completion Date
2028-12-31
Last Updated
2024-11-05
Healthy Volunteers
No
Interventions
Empagliflozin 10 MG
Once daily
Dapagliflozin 10 MG
Once daily
Locations (12)
Bispebjerg Hospital
Copenhagen, Denmark
Rigshospitalet
Copenhagen, Denmark
Herlev and Gentofte Hospital
Herlev, Denmark
Steno Diabetes Center Copenhagen
Herlev, Denmark
Nordsjællands Hospital
Hillerød, Denmark
Holbæk Sygehus
Holbæk, Denmark
Hvidovre Hospital
Hvidovre, Denmark
Sjællands Universitetshospital
Køge, Denmark
Nykøbing F. Sygehus
Nykøbing Falster, Denmark
Sjællands Universitetshospital
Roskilde, Denmark
Bornholms Hospital
Rønne, Denmark
Slagelse Sygehus
Slagelse, Denmark