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Monitoring Lupus Nephritis Through Urinary Extracellular Vesicles
Sponsor: Kolding Sygehus
Summary
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that can lead to irreversible kidney damage if not detected and managed promptly. LN is classified and treated based on its histopathological features obtained by invasive kidney biopsy. Recent research has suggested urinary extracellular vesicles (uEVs) as potential non-invasive biomarkers. The primary objective of this prospective study is to investigate the utility of uEVs in LN.
Official title: Monitoring and Detecting Lupus Nephritis Through Urinary Extracellular Vesicles in Urine
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2024-11-15
Completion Date
2030-05-01
Last Updated
2025-09-09
Healthy Volunteers
Yes
Conditions
Interventions
Kidney biopsy
Patient refered to kidney biopsy independent of the presented study
Urinary extracellular vesicle testing
Urinary extracellular vesicles will be isolated and tested for complement activation and other markers of kidney disease
Autoimmunity in plasma
Expected autoimmunity in plasma isolated from blood samples
Locations (4)
Kolding Hospital
Kolding, Denmark
Department of Nephrology
Odense, Denmark
Department of Rheumatology
Odense, Denmark
Univesity of Southern Denmark
Odense, Denmark