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RECRUITING
NCT06642402

Monitoring Lupus Nephritis Through Urinary Extracellular Vesicles

Sponsor: Kolding Sygehus

View on ClinicalTrials.gov

Summary

Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that can lead to irreversible kidney damage if not detected and managed promptly. LN is classified and treated based on its histopathological features obtained by invasive kidney biopsy. Recent research has suggested urinary extracellular vesicles (uEVs) as potential non-invasive biomarkers. The primary objective of this prospective study is to investigate the utility of uEVs in LN.

Official title: Monitoring and Detecting Lupus Nephritis Through Urinary Extracellular Vesicles in Urine

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

40

Start Date

2024-11-15

Completion Date

2030-05-01

Last Updated

2025-09-09

Healthy Volunteers

Yes

Interventions

DIAGNOSTIC_TEST

Kidney biopsy

Patient refered to kidney biopsy independent of the presented study

DIAGNOSTIC_TEST

Urinary extracellular vesicle testing

Urinary extracellular vesicles will be isolated and tested for complement activation and other markers of kidney disease

DIAGNOSTIC_TEST

Autoimmunity in plasma

Expected autoimmunity in plasma isolated from blood samples

Locations (4)

Kolding Hospital

Kolding, Denmark

Department of Nephrology

Odense, Denmark

Department of Rheumatology

Odense, Denmark

Univesity of Southern Denmark

Odense, Denmark