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Efficacy of Fresh Frozen Plasma (FFP) in Treating Thrombocytopenia in Dengue Patients
Sponsor: Sheikh Hasina National Institute of Burn and Plastic Surgery
Summary
This clinical trial seeks to assess the effectiveness of fresh frozen plasma (FFP) in the treatment of thrombocytopenia in individuals with dengue. Dengue is a viral infection marked by thrombocytopenia, potentially resulting in significant hemorrhagic consequences. FFP is frequently utilized in the management of coagulopathies, and this study will investigate its efficacy in enhancing platelet count and mitigating bleeding risks in dengue patients with thrombocytopenia. The research will be executed as a randomized, controlled trial to evaluate outcomes in patients receiving routine care with and without FFP transfusion.
Official title: Efficacy of Fresh Frozen Plasma (Ffp) in the Treatment of Thrombocytopenia in Dengue Patients
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2024-05-01
Completion Date
2024-12-31
Last Updated
2024-10-15
Healthy Volunteers
No
Interventions
Fresh frozen plasma
Intervention Type: Biological * Intervention Name: Fresh Frozen Plasma (FFP) * Detailed Description: * Dosage:Fresh frozen plasma (FFP) will be administered at a dose of 10-15 mL/kg body weight. * Administration: The FFP will be transfused intravenously under controlled clinical conditions. * Purpose: The transfusion aims to correct coagulopathy and normalize activated partial thromboplastin time (aPTT) in non-bleeding thrombocytopenic dengue patients. * Monitoring: Patients will be closely monitored for any adverse reactions or complications during and after the transfusion process. Coagulation parameters, including aPTT, will be measured at baseline, 24 hours, and 48 hours post-transfusion.
Locations (1)
SheikhHasinaNIBPS
Dhaka, Bangladesh