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STarting incrEmental Prescription of Peritoneal Dialysis
Sponsor: The University of Queensland
Summary
Kidney failure is fatal without dialysis. Peritoneal dialysis (PD) completed at home offers greater flexibility and autonomy for patients . However, PD is often prescribed for 24 hours/day, 7 days/week for every patient starting dialysis. This practice is not evidence-informed, may be unnecessary and potentially harmful. The STEP-PD trial aims to determine the optimal approach to commencing patients on PD through starting at low dose PD and incrementing over time.
Official title: An International, Multi-centre, Randomised Controlled Trial Co-designed With Consumers With Lived Experience of Peritoneal Dialysis (PD) to Determine the Optimal Approach to Starting Patients With Kidney Failure on PD
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
224
Start Date
2025-09-19
Completion Date
2029-09-30
Last Updated
2026-03-19
Healthy Volunteers
No
Conditions
Interventions
Incremental PD
Incremental PD: Commence PD using goal-directed PD prescription ≤14 exchanges/week for continuous ambulatory PD (CAPD) or ≤21 exchanges/week for automated PD (APD) with no day dwell until an indication for increase in the PD dose (trigger point) is reached.
Full dose PD
Full dose PD: Commence with 24 hours, 7 days/week PD (i.e., CAPD ≥28 exchanges/week or APD (overnight) with day dwell (i.e., no dry abdomen)).
Locations (6)
Blacktown
Blacktown, New South Wales, Australia
Princess Alexandra Hospital
Brisbane, Queensland, Australia
Eastern Health
Box Hill, Victoria, Australia
Hallym University Sacred Heart Hospital
Chuncheon, Gangwon-do, South Korea
Taichung Veterans General Hospital
Taichung, Xitun District, Taiwan
King Chulalongkorn Memorial Hospital
Bangkok, Pathum Wan, Thailand