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Age-related Changes in Retinal Oxygen Extraction in Healthy Subjects
Sponsor: Medical University of Vienna
Summary
It has been found that several systemic and ocular diseases are associated with impaired retinal oxygen extraction. In the present study, retinal oxygen extraction will be measured in different age groups in order to identify age related changes in otherwise healthy subjects. In addition, the study will explore short-term changes in retinal metabolism induced by breathing pure oxygen. Measurements will be performed with dynamic vessel analyzer and laser speckle flowgraphy to evaluate retinal blood flow and retinal oxygen saturation, in order to calculate retinal oxygen extraction.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-09-30
Completion Date
2026-01-31
Last Updated
2025-11-21
Healthy Volunteers
Yes
Interventions
Oxygen 100% Gas for Inhalation
SAUERSTOFF medizinisch, Messer GmbH, Industriestrasse 5, 2352 Gumpoldskirchen, Austria Dose: min. 95.5%, breathing for max. 45 minutes
Locations (1)
Department of Clinical Pharmacology, Medical University of Vienna, Austria
Vienna, Vienna, Austria