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NOT YET RECRUITING
NCT06643845
NA

Can Multimodal Medical Strategies Can Delay Total Knee Replacement?

Sponsor: University Hospital, Brest

View on ClinicalTrials.gov

Summary

Knee is the most common site of osteoarthritis. Treatment of knee osteoarthritis starts with a full course of medical therapy, followed by surgery to replace the knee with a prosthesis if this strategy fails, or in advanced cases. However, the new recommendations of the French rheumatology society, which evaluate the various treatments and position them in the treatment plan, are not well known, and the definition of a complete treatment remains unclear. The vast majority of patients are therefore referred to a surgeon after having tried a small part of the therapeutic arsenal (generally analgesics and corticosteroid or hyaluronic acid infiltrations). The goal of this study is to to select patients most likely to gain from surgery and to develop strategies that avoid the need for major surgery.

Official title: Is Non Surgical CaRE Using Treat to Target Multimodal meDIcal Strategies aBLE to Delay or Avoid Total Knee Replacement? (INCREDIBLE)

Key Details

Gender

All

Age Range

18 Years - 90 Years

Study Type

INTERVENTIONAL

Enrollment

1000

Start Date

2025-09

Completion Date

2031-03

Last Updated

2025-07-24

Healthy Volunteers

No

Interventions

PROCEDURE

arthroplasty

In the surgery arm, patients will have their surgery (arthroplasty), as originally planned.

OTHER

Medical and non-medical treatments

In the medical care arm, patients will follow multimodal medical strategies to prevent surgery in a population of patients with knee osteoarthritis having a first indication of knee prosthesis

Locations (21)

CHU Amiens

Amiens, France

CHU Brest

Brest, France

CHU Caen

Caen, France

CHD Vendée

La Roche-sur-Yon, France

CHU Le Mans

Le Mans, France

CHU Limoges

Limoges, France

GHICL- Hôpital Saint Philibert

Lomme, France

HCL

Lyon, France

CHU Montpellier

Montpellier, France

CH Morlaix

Morlaix, France

CHU Nantes

Nantes, France

CHU Nice

Nice, France

AP-HP Cochin

Paris, France

AP-HP La pitié

Paris, France

AP-HP Lariboisière

Paris, France

AP-HP Saint-Antoine

Paris, France

CHIC Quimper

Quimper, France

CHU Reims

Reims, France

CHU Saint Etienne

Saint-Etienne, France

CHU Strasbourg

Strasbourg, France

CHU Tours

Tours, France