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Can Multimodal Medical Strategies Can Delay Total Knee Replacement?
Sponsor: University Hospital, Brest
Summary
Knee is the most common site of osteoarthritis. Treatment of knee osteoarthritis starts with a full course of medical therapy, followed by surgery to replace the knee with a prosthesis if this strategy fails, or in advanced cases. However, the new recommendations of the French rheumatology society, which evaluate the various treatments and position them in the treatment plan, are not well known, and the definition of a complete treatment remains unclear. The vast majority of patients are therefore referred to a surgeon after having tried a small part of the therapeutic arsenal (generally analgesics and corticosteroid or hyaluronic acid infiltrations). The goal of this study is to to select patients most likely to gain from surgery and to develop strategies that avoid the need for major surgery.
Official title: Is Non Surgical CaRE Using Treat to Target Multimodal meDIcal Strategies aBLE to Delay or Avoid Total Knee Replacement? (INCREDIBLE)
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
1000
Start Date
2025-09
Completion Date
2031-03
Last Updated
2025-07-24
Healthy Volunteers
No
Conditions
Interventions
arthroplasty
In the surgery arm, patients will have their surgery (arthroplasty), as originally planned.
Medical and non-medical treatments
In the medical care arm, patients will follow multimodal medical strategies to prevent surgery in a population of patients with knee osteoarthritis having a first indication of knee prosthesis
Locations (21)
CHU Amiens
Amiens, France
CHU Brest
Brest, France
CHU Caen
Caen, France
CHD Vendée
La Roche-sur-Yon, France
CHU Le Mans
Le Mans, France
CHU Limoges
Limoges, France
GHICL- Hôpital Saint Philibert
Lomme, France
HCL
Lyon, France
CHU Montpellier
Montpellier, France
CH Morlaix
Morlaix, France
CHU Nantes
Nantes, France
CHU Nice
Nice, France
AP-HP Cochin
Paris, France
AP-HP La pitié
Paris, France
AP-HP Lariboisière
Paris, France
AP-HP Saint-Antoine
Paris, France
CHIC Quimper
Quimper, France
CHU Reims
Reims, France
CHU Saint Etienne
Saint-Etienne, France
CHU Strasbourg
Strasbourg, France
CHU Tours
Tours, France