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Progesterone-modified Natural Cycle for FET
Sponsor: Shandong University of Traditional Chinese Medicine
Summary
Hormone replacement therapy (HRT) cycles, despite the ease of synchronizing embryo thawing and embryo transfer timing, increase the risk of pregnancies and obstetric complications compared to natural cycles (NC). By ensuring the presence of the corpus luteum while reducing the number of monitoring sessions, the progesterone modified natural cycle (P4mNC) offers more convenience for the patient than the normal NC. This study is designed to compare the effects of P4mNC and HRT cycles on FET outcomes.
Official title: Comparison of Progesterone-modified Natural Cycle and Hormone Replacement Therapy Cycle for Endometrial Preparation in Single Frozen Blastocyst Transfer
Key Details
Gender
FEMALE
Age Range
21 Years - 44 Years
Study Type
INTERVENTIONAL
Enrollment
336
Start Date
2024-12-05
Completion Date
2027-12-01
Last Updated
2024-10-16
Healthy Volunteers
No
Conditions
Interventions
Progesterone-modified natural cycle preparation for frozen embryo transfer
A novel endometrial preparation protocol that optimizes the natural cycle, whereby as long as the thickness of the endometrium is suitable for embryo transfer, vaginal progesterone can be used to transform the endometrium before ovulation and subsequently FET.
Hormone replacement therapy cycle preparation for frozen embryo transfer
A traditional endometrial preparation protocol is used for FET, which involves using fixed or flexible exogenous estradiol for artificial cycles. This protocol typically involves starting exogenous estradiol on day 3 or 4 of the cycle, continuing for 7-10 days, and then discontinuing. Upon determining that the endometrial thickness meets the standard, progesterone conversion of the endometrium can be performed.