Clinical Research Directory

Inclusion Criteria: * Age ≥18 years, gender unrestricted; * Inpatients in the cardiology department and cardiovascular surgery department who are using warfarin for the first time and require continuous treatment for at least 3 months; * The patient or legal guardian agrees to the research plan and signs an informed consent form; Exclusion Criteria: * Patients with contraindications to anticoagulant therapy or those who are scheduled for surgery in the near future; * Known genotypes CYP2C9 or VKORC1; * Patients scheduled to undergo interventional procedures (such as radiofrequency ablation, cardiac defibrillation) in the near future; * Patients with hematological disorders, bleeding disorders, or a tendency to bleed; * Patients with severe liver and kidney dysfunction (CrCl \< 15ml/min); * Patients with concurrent tumors, severe immune system diseases, or other terminal diseases; * Patients with severe heart failure (NYHA Class IV) or severe anemia (hemoglobin \< 60g/L); * Pregnant and lactating women; * Uncontrolled hypertension (systolic blood pressure \> 180mmHg or diastolic blood pressure \> 120mmHg).