Clinical Research Directory

Inclusion Criteria: * Inclusion Criteria of participants: * Periodontally and systemic healthy patients * Patients aged \> 18 years * Non- restored teeth for many reasons (i.e. endodontic failure, unworthy for treatment in deep caries/non-caries lesion and root fracture), locate in the posterior area in the maxillary or mandibular arch indicate for customized implant with no need for additional bone and soft tissue augmentation procedures. * An adequate vertical bone for immediate implant placement. * Implants will be positioned with adequate primary stability so that transmucosal healing can be accomplished. * No taken medications known to interfere healing or periodontal tissue health or bone metabolism. * No previous periodontal surgery at involved sites. * Good oral hygiene and good compliance with the plaque control instructions following initial therapy. Exclusion criteria: * Patients with active periodontal diseases (bleeding on probing- probing depth \> 4 mm) or those under orthodontic treatment. * Poor oral hygiene (full mouth plaque score \> 25% and full mouth bleeding score \> 25%) * Smoking habits (\> 10 cigarettes/day) * Severe acute or chronic periodontitis * Severe bruxism habits * History of oral/IV bisphosphonates taking * Remote or recent radiation therapy in the oro-maxillo-facial area or recent chemotherapy. * Xerostomia * Pregnant and lactating mothers * Patients who have been received periodontal surgery in the study area during the last year. * Clinical or radiographic signs of periapical pathology contraindicating immediate implant placement. * Implants showing signs of peri-implant mucositis and peri-implantitis during the study period will be excluded from the following analyses.