Clinical Research Directory

TMS With Real-time E-field and EEG Source Imaging

Sponsor: Brigham and Women's Hospital

Summary

The goal of this study is to develop and validate an approach for accurate targeting and stimulation of brain networks using transcranial magnetic stimulation (TMS) using information from magnetic resonance imaging (MRI) data. This study requires two visits from each participant. In the first visit, the participant will be scanned by MRI scanners to collect data from the brain. Next, the data will be analyzed by the researcher to model the connections between different regions of the brain to determine the stimulation areas related to the so-called frontoparietal network. In the second visit, the participants will take four TMS sessions with different types of stimulations applied to the computed targets and complete a computer-based task named multi-source interference task. Electroencephalogram (EEG) data will be collected during the TMS stimulations and tasks. The main hypothesis is that applying TMS stimulations to the brain targets reduces the response time and response error in the tasks.

Official title: Precision TMS With Integrated Visualization and Analysis of Real-time E-field and EEG Source Imaging

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