Clinical Research Directory
Browse clinical research sites, groups, and studies.
Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke
Sponsor: Seoul National University Hospital
Summary
Lipid-lowering therapy constitutes a cornerstone of secondary prevention in ischemic stroke; however, current stroke guidelines remain deficient in providing optimal target low-density lipoprotein (LDL)-cholesterol levels tailored to the stroke subtypes. Most clinical trials on LDL-cholesterol management have not differentiated between stroke subtypes or have primarily focused on large artery atherosclerosis (LAA) stroke, leaving a gap in evidence for managing LDL-cholesterol in other stroke subtypes, e.g., small vessel occlusion (SVO) stroke. While hypertension is the leading risk factor for SVO strokes, the link between elevated LDL-cholesterol and SVO stroke is also recognized. Establishing optimal LDL-cholesterol targets for SVO stroke would significantly enhance secondary prevention strategies and improve patient outcome. Thus, the investigators aim to compare intensive versus standard lipid-lowering in patients with SVO stroke. SVO70 is a multicenter, prospective, randomized, open, blinded-endpoint clinical trial. Adult participants with objectively confirmed SVO stroke within 180 days of randomization will be included. Exclusion criteria include those with predefined LDL-cholesterol targets for other conditions, statin contraindications, or women who are pregnant, breastfeeding, or planning pregnancy during the study period. Eligible participants will be randomized 1:1 to target LDL-cholesterol \<70 mg/dL (intensive group) or 90-110 mg/dL (standard group). The trial plans to enroll 4,016 participants, with the primary outcome being major adverse cardiovascular events-cardiovascular death, stroke, and acute coronary syndrome-during a follow-up period of at least 4 years. This study would provide valuable information for determining the optimal LDL-cholesterol target for patients with SVO stroke.
Official title: Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke (SVO70)
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
4016
Start Date
2024-10-04
Completion Date
2030-09
Last Updated
2025-05-21
Healthy Volunteers
No
Conditions
Interventions
Statins and/or Ezetimibe
Statin ± Ezetimibe to achieve target LDL-cholesterol level
PCSK9 inhibitor
The use of PCSK9 inhibitors is permitted to achieve target LDL-cholesterol levels in participants who did not reach the target with statins ± ezetimibe.
Locations (46)
Korea University Ansan Hospital
Ansan, South Korea
Hallym University Sacred Heart Hospital
Anyang, South Korea
Pusan National University Hospital
Busan, South Korea
Gyeongsang National University Changwon Hospital
Changwon, South Korea
Samsung Changwon Hospital
Changwon, South Korea
Chungbuk National University Hospital
Cheongju-si, South Korea
Hallym University Chuncheon Sacred Heart Hospital
Chuncheon, South Korea
Kangwon National University Hospital
Chuncheon, South Korea
Daegu Catholic University Medical Center
Daegu, South Korea
Keimyung University Dongsan Medical Center
Daegu, South Korea
Kyungpook National University Chilgok Hospital
Daegu, South Korea
Kyungpook National University Hospital
Daegu, South Korea
Chungnam National University Hospital
Daejeon, South Korea
Daejeon Eulji Medical Center
Daejeon, South Korea
Dongguk University Ilsan Hospital
Goyang, South Korea
Ilsan Paik Hospital
Goyang, South Korea
National Health Insurance Service Ilsan Hospital
Goyang, South Korea
Hanyang University Guri Hospital
Guri-si, South Korea
Chonnam National University Hospital
Gwangju, South Korea
Chosun University Hospital
Gwangju, South Korea
Chung-Ang University Gwangmyeong Hospital
Gwangmyeong, South Korea
Dongtan Sacred Heart Hospital
Hwaseong, South Korea
Wonkwang University Hospital
Iksan, South Korea
Gachon University Gil Medical Center
Incheon, South Korea
Inha University Hospital
Incheon, South Korea
International St. Mary's Hospital
Incheon, South Korea
Jeju National University Hospital
Jeju City, South Korea
Seoul National University Bundang Hospital
Seongnam, South Korea
Asan Medical Center
Seoul, South Korea
Chung-Ang University Hospital
Seoul, South Korea
Ewha Womans University Mokdong Hospital
Seoul, South Korea
Ewha Womans University Seoul Hospital
Seoul, South Korea
Gangnam Severance Hospital
Seoul, South Korea
Hallym University Kangdong Sacred Heart Hospital
Seoul, South Korea
Hanyang University Seoul Hospital
Seoul, South Korea
Konkuk University Medical Center
Seoul, South Korea
Korea University Anam Hospital
Seoul, South Korea
Kyung Hee University Medical Center
Seoul, South Korea
National Medical Center
Seoul, South Korea
Nowon Eulji Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Seoul Metropolitan Government-Seoul National University Boramae Medical Center
Seoul, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital
Seoul, South Korea
Yeouido St. Mary's Hospital
Seoul, South Korea
Yongin Severance Hospital
Yŏngin, South Korea