Clinical Research Directory

Inclusion Criteria: * Participant having freely given his oral agreement. * Participant with a major sickle cell syndrome, regardless of genotype (e.g. SS, SC, Sbeta). * Participant with a sufficient command of spoken and written French to take the assessments, complete the questionnaires, follow the program sessions and carry out the home exercises. Exclusion Criteria: * Participant with one or more severe psychiatric pathologies (e.g. severe depression, psychosis) that could interfere with the conduct of the study, in particular the primary and secondary endpoints. * Participants with another chronic pathology causing fatigue. * Participants in vaso-occlusive crisis (VOC) or hospitalization. * Participant under legal protection (guardianship, curatorship, safeguard of justice, deprived of liberty).