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Impact of Breast Milk miRNAs on the Infant Gut Microbiota
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The first 1000 days of life are a critical period for future health. A healthy gut microbiota (GM) is essential for preventing both short-term and long-term health issues. Breast milk (BM) plays a key role in establishing the GM, as, unlike formula milk, it contains miRNAs that may interact with and modulate the microbiota. Primary Objective: To study the effect of BM on the composition of fecal miRNAs in exclusively breastfed infants compared to those fed with formula milk at different times (D10, D30, D60, M6, M12). Secondary Objectives: Analyze the effect of BM miRNAs on infant fecal microbiota, taking environmental confounding factors into account. Study the influence of BM microbiota on miRNA profiles in the milk. Examine the effect of BM microbiota on the infants' gut microbiota. Explore the links between BM miRNAs, infant gut microbiota, and intestinal inflammation.
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2024-11-01
Completion Date
2027-05-31
Last Updated
2024-10-21
Healthy Volunteers
Yes
Conditions
Interventions
Stool analysis
Analysis of infant fecal microbiota
breast milk analysis
Analysis of the effect of breast milk miRNAs on infant fecal microbiota
Locations (1)
Robert Debre Hospital Assistance Publique Hôpitaux de Paris
Paris, France