Clinical Research Directory

Inclusion Criteria: * Patient referred for diagnostic colonoscopy * Age between 40 and 85 years old * Ability of normal oral ingestion * Able to give informed consent by the patient or the legal representative Exclusion Criteria: * Participant has a history of (partial) colectomy, excluding appendectomy * Inability of oral ingestion * Chronic severe constipation, defined as the need for daily laxative use of any kind or the need to use laxatives to obtain defaecation. * Uncontrolled coagulopathy * Pregnancy * Premenopausal women not adhering to any contraceptive method * Inflammatory bowel disease * Lynch syndrome * Familial adenomatosis polyposis syndrome * Serrated polyposis syndrome * hypersensitivity to the active substances of PLENVU as listed in the SmPC section 6.1 * gastrointestinal obstruction or perforation * ileus * gastric emptying disorders (e.g. gastroparesis, gastric retention, etc.) * phenylketonuria (due to the presence of aspartame in PLENVU) * glucose-6-phosphate dehydrogenase deficiency (due to the presence of ascorbate in PLENVU) * toxic megacolon * Any disorder, which in the Investigator's opinion might jeopardise the participant's safety or compliance with the protocol * Any prior or concomitant treatment(s) that might jeopardise the participant's safety or that would compromise the integrity of the Trial