Clinical Research Directory

Inclusion Criteria 1. Children aged 5-17; 2. Removing flexible lenses for at least 1 week, flexible astigmatism and hard lenses for at least 3 weeks, orthokeratology lenses for at least 3 months; 3. Best corrected visual acuity of either eye were all ≥ 1.0; 4. The range of myopia in either eye was -15 D ≤ SE ≤ +2.0 D; 5. Astigmatism of either eye less than -5.0 D; 6. Anisometropia ≤ -1.5 D; 7. There was no active ocular inflammatory diseases; no obvious corneal cloud or macula, anormal corneal topography, and no tendency of keratoconus. 8. Intraocular pressure of either eye is of 10 to 21 mmHg; 9. On the basis of full understanding, children and their guardians sign the informed consent; Exclusion Criteria: 1. Amblyopia: best corrected visual acuity (BCVA) of either eye less than 1.0 for children over 6 years old; 2. Active ocular inflammatory diseases, such as uveitis and other inflammatory diseases; 3. Secondary myopia, genetic disease or connective tissue- related myopia; 4. Moderate or severe ptosis; 5. Congenital cataract, glaucoma; 6. Other fundus diseases other than myopic related fundus lesions; 7. Intraocular or refractive surgery history; 8. The refractive medium is turbid, and it is impossible to take a clear fundus image; (9)Unable to cooperate with fundus image shooting and other examination; (10)Do not receive cycloplegia or have contraindications; (11)Poor overall condition, unable to follow up for a long time; (12)The subject refuses to participate in the research; (13)Other cases in which the researcher judges that it is not suitable for participation in the study.