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Exposure to Organochlorine Pollutants and Impact on Development in the Peripubertal Age in Guadeloupe
Sponsor: Centre Hospitalier Universitaire de la Guadeloupe
Summary
In the context of environmental pollution of the French West Indies by chlordecone and questions about health consequences, monitoring at the peripubertal age of children born alive in the TIMOUN cohort is justified in several respects: - existence of an already established mother-child cohort whose live-born children will reach peripubertal ages during the period 2020-2022; - opportunity to verify hypotheses put forward on the basis of toxicological data acquired in laboratory animals and the hormonal characteristics of chlordecone (endocrine disruptor); - strong societal demand for such research to be carried out because of concerns about the sensitivity of children and adolescents to the effects of environmental xenobiotics, in particular on sexual development and the age of puberty; - recommendation of the Scientific Council Chlordecone Inserm - InVS; specific action of the National Plan Chlordecone IV.
Key Details
Gender
All
Age Range
16 Years - 22 Years
Study Type
OBSERVATIONAL
Enrollment
650
Start Date
2022-12-19
Completion Date
2026-12-19
Last Updated
2025-11-17
Healthy Volunteers
No
Conditions
Interventions
Clinical examination
For the aim of the present study, we will follow-up children born alive in the TIMOUN cohort at peripubertal age. Questionnaires will be administered to parents on the child's health and lifestyle. Stature-weight anthropometric and cardio-dynamic measurements of the child will be obtained. Scores on three cognitive tests will be obtained. Furthermore, steroid hormones and chlordecone in the child's peripheral blood will be determined.
Locations (1)
CHU of Guadeloupe
Pointe-à-Pitre, Guadeloupe, Guadeloupe