Clinical Research Directory

Inclusion criteria: 1. Written, informed consent. 2. Age 18 years or older. 3. Recurrent kidney stone disease (2 or more stone episodes in the last 10 years). 4. Last kidney stone containing 50% or more of CaOx, CaP or a mixture of both. 5. If taking guideline-recommended medications for kidney stone prophylaxis (e.g. citrate salts) patients must have been on a stable regimen for at least 60 days before randomization, and willing to remain on this stable regimen for the duration of the study. Exclusion criteria: 1. Patients with a known history of secondary or Mendelian causes of calcium nephrolithiasis 2. Type I diabetes mellitus 3. History of ketoacidosis 4. Treatment with SGLT2 Inhibitor 5. CKD (defined as CKD-EPI eGFR \<30 mL/min) 6. Kidney transplant recipient 7. History of recurrent urinary tract infections (\>3 episodes/year) 8. Active cancer treatment 9. Less than 3-year life expectancy 10. Pregnancy and breastfeeding 11. Inability to understand and follow the study protocol 12. Known allergy to the study drug 13. Concomitant participation in another interventional clinical trial