Clinical Research Directory

Inclusion Criteria: * The investigators enrolled individuals of both genders, aged between 18 and 75, * All patients had acute first-ever embolic ischemic stroke and were eligible for thrombolysis. * All patients had Atrial fibrillation Exclusion Criteria: * The investigators excluded patients who had alteplase contraindications * The investigators excluded patients who did not receive the total dose of alteplase for any reason. * The investigators excluded patients who had a known history of persistent or recurrent CNS pathology (e.g., epilepsy, meningioma, multiple sclerosis) * The investigators excluded patients who had recurrent ischemic stroke diagnosed by appropriate clinical history and/or MRI brain findings. * The investigators excluded patients with symptoms of major organ failure, active malignancies, or an acute myocardial infarction within the previous six weeks. * The investigators also excluded pregnant and lactating patients with stroke due to venous thrombosis and stroke following cardiac arrest.