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A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)
Sponsor: Kura Oncology, Inc.
Summary
In this clinical trial, the safety, tolerability, and preliminary antitumor activity of ziftomenib in combination with imatinib will be evaluated in adults with gastrointestinal stromal tumors (GIST) who have been treated previously with imatinib.
Official title: A Phase 1a/1b Study of the Safety, Pharmacokinetics, and Antitumor Activity of the Oral Menin Inhibitor Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST) After Imatinib Failure
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
157
Start Date
2025-03-27
Completion Date
2028-12
Last Updated
2026-02-05
Healthy Volunteers
No
Conditions
Interventions
ziftomenib
menin inhibitor
imatinib mesylate
kinase inhibitor
Locations (32)
University of Alabama at Birmingham
Birmingham, Alabama, United States
Mayo Clinic Cancer Center
Phoenix, Arizona, United States
University of California, San Diego
La Jolla, California, United States
University of Southern California
Los Angeles, California, United States
University Of California, Irvine
Orange, California, United States
Stanford Cancer Institute
Palo Alto, California, United States
UCLA Santa Monica Medical Center
Santa Monica, California, United States
University of Colorado Cancer Center
Aurora, Colorado, United States
Sarah Cannon Research Institute
Denver, Colorado, United States
Yale University School of Medicine
New Haven, Connecticut, United States
Mayo Clinic Cancer Center
Jacksonville, Florida, United States
University of Miami
Miami, Florida, United States
Northwestern University
Chicago, Illinois, United States
University of Iowa
Iowa City, Iowa, United States
Johns Hopkins University
Baltimore, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Harvard University
Boston, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, United States
Memorial Sloan-Kettering Cancer Center
New York, New York, United States
Duke University Medical Center
Durham, North Carolina, United States
Ohio State University
Columbus, Ohio, United States
Oregon Health & Science University
Portland, Oregon, United States
Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Temple University Health System
Philadelphia, Pennsylvania, United States
Sarah Cannon Research Institute
Nashville, Tennessee, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Sarah Cannon Research Institute
Dallas, Texas, United States
University of Texas
Houston, Texas, United States
University of Texas Health Science Center
San Antonio, Texas, United States
University of Utah
Salt Lake City, Utah, United States
Medical College of Wisconsin
Milwaukee, Wisconsin, United States