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RECRUITING
NCT06656819

The Modulatory Effect of Female Sex Hormones on Spinal Neuroplasticity

Sponsor: University of Texas Southwestern Medical Center

View on ClinicalTrials.gov

Summary

The goal of this project is to test our central hypothesis that the spinal cord neuroplasticity in females will be modulated by the level of estradiol concentration. under aim 1 we will determine the influence of estradiol fluctuations on spinal circuit excitability post afferent (sensory) mediated subthreshold motor priming in young healthy females and males. We will use an established repetitive peripheral nerve electrical stimulation with a stimulation intensity below the motor threshold to prime the spinal motor circuits. under aim 2 we seek to characterize the input output property of spinal circuit excitability after descending drive (motor) mediated priming in young healthy male participants. in aim 3 we will examine the influence of estradiol fluctuations on descending drive mediated motor priming in young healthy females.

Official title: TMSpine: The Modulatory Effect of Female Sex Hormones on Spinal Neuroplasticity

Key Details

Gender

All

Age Range

18 Years - 39 Years

Study Type

OBSERVATIONAL

Enrollment

50

Start Date

2020-07-01

Completion Date

2027-12-31

Last Updated

2026-03-30

Healthy Volunteers

Yes

Conditions

Interventions

DEVICE

Magstim Rapid2

AIM 1: Investigate the estradiol effect on spinal circuit excitability post afferent (sensory) mediated subthreshold motor priming in young healthy women and men. AIM 2: Characterize the Input output property of spinal circuit excitability following descending drive (motor) mediate priming in young healthy participants AIM 3: Examine the estradiol effect on spinal circuit excitability following descending drive (motor) mediated priming in young healthy females

Locations (1)

University of Texas Southwestern Medical Center

Dallas, Texas, United States