Clinical Research Directory
Browse clinical research sites, groups, and studies.
The Modulatory Effect of Female Sex Hormones on Spinal Neuroplasticity
Sponsor: University of Texas Southwestern Medical Center
Summary
The goal of this project is to test our central hypothesis that the spinal cord neuroplasticity in females will be modulated by the level of estradiol concentration. under aim 1 we will determine the influence of estradiol fluctuations on spinal circuit excitability post afferent (sensory) mediated subthreshold motor priming in young healthy females and males. We will use an established repetitive peripheral nerve electrical stimulation with a stimulation intensity below the motor threshold to prime the spinal motor circuits. under aim 2 we seek to characterize the input output property of spinal circuit excitability after descending drive (motor) mediated priming in young healthy male participants. in aim 3 we will examine the influence of estradiol fluctuations on descending drive mediated motor priming in young healthy females.
Official title: TMSpine: The Modulatory Effect of Female Sex Hormones on Spinal Neuroplasticity
Key Details
Gender
All
Age Range
18 Years - 39 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2020-07-01
Completion Date
2027-12-31
Last Updated
2026-03-30
Healthy Volunteers
Yes
Conditions
Interventions
Magstim Rapid2
AIM 1: Investigate the estradiol effect on spinal circuit excitability post afferent (sensory) mediated subthreshold motor priming in young healthy women and men. AIM 2: Characterize the Input output property of spinal circuit excitability following descending drive (motor) mediate priming in young healthy participants AIM 3: Examine the estradiol effect on spinal circuit excitability following descending drive (motor) mediated priming in young healthy females
Locations (1)
University of Texas Southwestern Medical Center
Dallas, Texas, United States