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Different Flow Rates on Gas Exchange in Children During Apnea
Sponsor: Yasser S Mostafa, MD
Summary
Background: Children desaturate rapidly during apnea following anesthetic induction. The optimal apneic oxygenation flow rate and its effect on CO2 accumulation remain unclear. Objective: To compare nasal oxygen at 2, 4, and 8 L/min on the rise in arterial partial pressure of CO2 (PaCO2) between minutes 2 and 3 of apnea (primary outcome), oxygenation, and safety in anesthetized children.
Official title: Effect of Nasal Oxygen at 2, 4, and 8 L/Min on PaCO₂ and PaO₂ During Apneic Oxygenation in Anesthetized Children: A Prospective Randomized Trial
Key Details
Gender
All
Age Range
1 Year - 6 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2024-10-01
Completion Date
2026-06-01
Last Updated
2026-10-07
Healthy Volunteers
No
Conditions
Interventions
nasal cannula
After induction, bag-mask ventilation with 100% oxygen and flow rates of 6 L/ min will be carried out until the expired oxygen concentration will be \>90%, saturation of oxygen was 100%, and end tidal carbon dioxide was 30-40 mmHg. Once this will be reached, bag-mask ventilation will be stopped and apneic oxygenation will be initiated for 3 minutes
Locations (1)
Fayoum University Hospital
Al Fayyum, Faiyum Governorate, Egypt