Clinical Research Directory

Inclusion Criteria: * Participants in this study must be 21 years to 65 years of age and provide a driver's license or other state-issued ID. * Participants must also be sufficiently fluent in English to provide informed consent and understand questionnaires and instructions for laboratory procedures. * Participants must report drinking of, on average, at least 1 drink 3 days/week over the past 6 months. * Meet Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for myalgia (masticatory muscle pain), arthralgia (TMJ pain), or a combination (Schiffman et al., 2014) (TMD group only). * Own a smartphone with internet access. * Use of prescription medications will be allowed, provided they do not contraindicate alcohol use. Exclusion Criteria: * Use of opioid analgesics within the past month; * Current major depression; * History of any psychotic disorder; * Under-controlled hypertension or diabetes (as reflected by self-report); neurological disease (e.g., multiple sclerosis, epilepsy, amyotrophic lateral sclerosis, Parkinson's disease); * Serious medical illness (e.g., hepatitis, HIV/AIDS); * Impaired cognitive function; * History of substance use disorder (including nicotine/tobacco); * Alcohol naïve * Alcohol use disorder, or currently attempting to quit or cut down on using alcohol * Positive pregnancy test * Breastfeeding or intending to become pregnant * Loss of sensation in the lower leg * Inability to complete study tasks due to weakness, immobilization, or loss of limbs * Chronic pain (Control group only) * A urine-based drug screen for tetrahydrocannabinol, cocaine, benzodiazepines, morphine, and methamphetamine (Innovacon, Inc., San Diego, CA) will be performed. Participants testing positive for any substance will be discontinued. * Medications that contraindicate alcohol use