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Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study
Sponsor: Research and Treatment Society of Genetic Disorders
Summary
The goal of this observational study is to investigate the genetic and epigenetic mechanisms that may contribute to the development of Autism Spectrum Disorder (ASD) in individuals of different age groups. The study aims to explore how genetic variants and environmental factors interact to influence the risk of ASD. The main questions it aims to answer are: * Which genetic variants are most strongly associated with the development of ASD? * How do environmental factors, such as prenatal exposure, influence these genetic risks? * Can the combination of genetic and epigenetic data improve early detection or intervention strategies for ASD? Participants will: * Provide biological samples for genetic and epigenetic analysis. * Complete detailed questionnaires regarding environmental exposures and family history. * Participate in clinical assessments to evaluate the severity of ASD symptoms. Researchers will compare genetic and environmental data between individuals with ASD and those without the disorder to understand how these factors may contribute to the risk of ASD. This multi-center study will take place across several universities and hospitals in Türkiye, focusing on the potential interplay between inherited genetic factors and environmental influences.
Official title: A Multi-Center Multi-Omics Approach for Investigating Genetic and Epigenetic Mechanisms in Autism Spectrum Disorder
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
3000
Start Date
2025-12-27
Completion Date
2028-05-27
Last Updated
2024-10-29
Healthy Volunteers
Yes
Conditions
Locations (20)
Konya Selcuk University Faculty of Medicine, Department of Child and Adolescent Psychiatry
Konya, Selçuklu, Turkey (Türkiye)
Konya Selcuk University Faculty of Medicine, Department of Psychiatry
Konya, Selçuklu, Turkey (Türkiye)
Afyonkarahisar University of Health Sciences, Faculty of Medicine, Department of Child and Adolescent Psychiatry
Afyonkarahisar, Turkey (Türkiye)
Ankara Başkent University, Department of Psychiatry
Ankara, Turkey (Türkiye)
Ankara Gazi Faculty of Medicine, Department of Child and Adolescent Psychiatry
Ankara, Turkey (Türkiye)
Ankara SBÜ Gülhane Faculty of Medicine, Department of Child and Adolescent Psychiatry
Ankara, Turkey (Türkiye)
Bursa Uludağ University, Department of Child and Adolescent Psychiatry
Bursa, Turkey (Türkiye)
Denizli Pamukkale University Faculty of Medicine, Department of Child and Adolescent Psychiatry
Denizli, Turkey (Türkiye)
Erzurum Atatürk University Faculty of Medicine, Department of Child and Adolescent Psychiatry
Erzurum, Turkey (Türkiye)
Gaziantep University, Department of Child and Adolescent Psychiatry
Gaziantep, Turkey (Türkiye)
Giresun University, Department of Child and Adolescent Psychiatry
Giresun, Turkey (Türkiye)
Istanbul Cerrahpasa Faculty of Medicine, Department of Child and Adolescent Psychiatry
Istanbul, Turkey (Türkiye)
Istanbul Medeniyet University Faculty of Medicine, Department of Child and Adolescent Psychiatry
Istanbul, Turkey (Türkiye)
Istanbul Medeniyet University, Department of Psychiatry
Istanbul, Turkey (Türkiye)
Istanbul Çam and Sakura City Hospital, Department of Child and Adolescent Psychiatry
Istanbul, Turkey (Türkiye)
Izmir Katip Çelebi Faculty of Medicine, Department of Child and Adolescent Psychiatry
Izmir, Turkey (Türkiye)
Konya Necmettin Erbakan University Faculty of Medicine, Department of Child and Adolescent Psychiatry
Konya, Turkey (Türkiye)
Konya Selcuk University Faculty of Medicine, Department of Medical Genetics
Konya, Turkey (Türkiye)
Şanlıurfa Harran University Faculty of Medicine, Department of Child and Adolescent Psychiatry
Sanliurfa, Turkey (Türkiye)
Trabzon Karadeniz Technical University Faculty of Medicine, Department of Child and Adolescent Psychiatry
Trabzon, Turkey (Türkiye)