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Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery
Sponsor: Konkuk University Medical Center
Summary
The impact of acute normovolemic hemodilution (ANH) using hydroxyethyl starch before initiating cardiopulmonary bypass (CPB) on whole blood viscoelastic profile after CPB has not been well established. Patients undergoing cardiac surgery employing moderate hypothermic CPB are randomly allocated into one of two groups: in Group-ANH, ANH is applied by using a balanced hydroxyethyl starch (HES 130/0.6); and in Group-C, ANH is not applied. After weaning from CPB, intergroup differences of INTEM, EXTEM, FIBTEM, and APTEM profiles are analyzed. As a primary outcome, the inter-group differences between maximal clot firmness of EXTEM will be determined at 10 min after ANH in Group-ANH and that at control.
Official title: Impact of Mild Acute Normovolemic Hemodilution on Pre-bypass Coagulation Function During Cardiac Surgery
Key Details
Gender
All
Age Range
19 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2024-10-28
Completion Date
2025-04-30
Last Updated
2024-10-31
Healthy Volunteers
No
Interventions
Acute normovolemic hemodilution (ANH)
applying acute normovolemic hemodilution (ANH) by using HES 130/0.4 of 5 ml/kg before the initiation of cardiopulmonary bypass
hydroxyethyl starch (HES 130/0.6)
hydroxyethyl starch (HES 130/0.6)
Locations (2)
Konkuk University Medical Center
Seoul, Seoul, South Korea
Konkuk University Medical Center
Seoul, South Korea