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Cardiovascular Health in Adult Patients With Cancer Exposed to Cardiotoxic Therapies
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Summary
The goal of this observational study is to evaluate the cardiovascular health and prognosis of adult patients with cancer, treated with cardiotoxic therapies. The main purposes of the study are the following: * Identify the demographic factors related to the onset of cardiotoxicity produced by anticancer drugs. * Identify any subgroups more likely to develop distant major adverse cardiovascular events (MACE). * Evaluate the usefulness of clinical, biohumoral and echocardiographic parameters for early diagnosis of cardiotoxicity. Participants will be monitored during the anticancer treatment via clinical, laboratory and instrumental evaluation according to the recommendation of the current guidelines on Cardio-Oncology (European Society of Cardiology, 2022). Initial follow-up will be 2 years.
Official title: Cardiovascular Health and Prognosis in Adult Patients With Cancer Exposed to Cardiotoxic Therapies, an Observational Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2025-02-28
Completion Date
2028-12-15
Last Updated
2025-03-04
Healthy Volunteers
No
Conditions
Interventions
ECHOCARDIOGRAPHY
A complete echocardiographic exam will be performed during each cardio-oncologic evaluation.
ELECTROCARDIOGRAPHY (ECG)
An ECG tracing will be obtained during each cardio-oncologic evaluation.
LABORATORY TESTS
The cardiac biomarkers high-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) will be dosed according to the current recommendations of Cardio-Oncology Guidelines.
Locations (1)
Fondazione Policlinico Universitario A. Gemelli IRCCS;UOSD diagnostica cardiologica non invasiva
Rome, Lazio, Italy