Clinical Research Directory

The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain

Sponsor: University of Aarhus

Summary

The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart. The investigator hypothesize that: * An acute increase in lactate plasma concentration will decrease cerebral glucose uptake and increase cerebral blood flow * An acute increase in lactate plasma concentration will decrease palmitate and glucose uptake in the myocardium, and increase myocardial perfusion

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Locations (2)