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Comparison of the Bioavailability of the Flavanol of Grape Extracts
Sponsor: University of Ulster
Summary
Polyphenols are a group of naturally occurring compounds found in cocoa, teas, and grape seed extracts (GSE) that have been linked to various health benefits. This study will provide a greater insight into the relationship between polyphenol consumption and health, and could be used to help with the development of functional food products and novel supplements. Although the advantages of a polyphenol-rich diet are well-established, the bioavailability of GSE (a source of polyphenols) in the context of human digestion and beneficial properties are poorly understood. The investigators will conduct an open-label, randomized, 4-way crossover design with the aim to explore the bioavailability of GSE-derived flavan-3-ols from GSE and their related microbial metabolites and advance understanding of the bioactive properties of flavan-3-ols contributing to the development of more effective dietary strategies and functional food products.
Official title: Comparison of the Bioavailability of the Flavanol of Grape Extracts Administered in Capsule or in Gummy: a 4-way Randomized Crossover Study in Healthy Participants
Key Details
Gender
MALE
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2024-10-28
Completion Date
2025-09-01
Last Updated
2024-10-30
Healthy Volunteers
Yes
Conditions
Interventions
Polyphenol extract
Single dose
Locations (1)
Ulster University,Human Intervention Studies UnitColeraine, Co. Londonderry BT521SA
Coleraine, Co. Londonderry, United Kingdom