Clinical Research Directory

Inclusion Criteria for bipolar patients or offspring of bipolar parents: * Any current mood state (in the case of bipolar subjects) * For bipolar patients: DSM-V criteria for BD type I, BD type II, or BD NOS, as per the administration of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID) * For the offspring of bipolar parents: at least one parent meeting DSM-V criteria for BD type I or BD type II, or BD NOS as per the administration of the MINI Adult Exclusion Criteria for bipolar patients or offspring of bipolar parents: * Autism Spectrum Disorder (ASD) * Developmental Intellectual Disorder * Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis) * Schizophrenia * Uncontrolled or severe medical problem per investigator judgment * For the offspring: parents with a history of any brain diseases, including seizures, stroke, meningitis, encephalitis, dementia, and other degenerative brain diseases; parents with a history of intellectual disability Exclusion Criteria for healthy control subjects: * Any Psychiatric Diagnosis * Any family history of Bipolar Disorder, Psychotic Disorder, Schizophrenia, or Schizoaffective disorder in a first-degree relative * Any family history of a neurological condition in a first-degree relative. * Mental Retardation/Intellectual Disability * Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis) * Schizophrenia * Uncontrolled or severe medical problem per investigator judgement Exclusion criteria for annual visits: * Autism Spectrum Disorders (ASD) * Intellectual Developmental Disorder * Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis) * Schizophrenia * Uncontrolled or severe medical problem per investigator judgement