Clinical Research Directory

Inclusion Criteria: * 1\. Age ≥ 18 years old, and gender is not limited. * 2\. Meets the diagnostic criteria of Sepsis (Sepsis-3): In patients with infection or suspected infection, Sepsis is diagnosed when the Sequential (Sepsis related) Organ Failure Assessment (SOFA) score increased by ≥2 points from baseline. * 3\. Patients or their legal representatives understand and voluntarily sign the informed consent for this study. Exclusion Criteria: * 1\. Patients with lower extremity denervation. * 2\. Patients with lower extremity amputation or congenital disability with lower limb hypoplasia. * 3\. Patients with severe acute trauma such as active bleeding or unfixed fractures in the lower extremities. * 4\. Patients with skin damage, infection, bleeding, or hematoma near the lower extremity acupuncture site. * 5\. Patients with implantable medical devices, such as pacemakers, implantable cardioverter defibrillators (ICD) or deep brain stimulation (DBS). * 6\. Patients who are pregnant, breast feeding during the study. * 7\. Patients whose expected duration of ICU length of stay is less than 48 hours. * 8\. Patients whose legal representatives refuse routine active treatment and sign palliative treatment consent. * 9\. Patients who are currently participating in another randomized clinical trial. * 10\. Patients or their legal representatives refused to participate in the study or were unable to sign informed consent. * 11\. Immunosuppressive status, including but not limited to: congenital immunosuppressive patients, AIDS patients, organ transplant patients, long-term use of immunosuppressive patients, patients receiving tumor radiotherapy or chemotherapy within 1 month; * 12\. Patients with an anticipated survival prognosis of no more than 7 days due to advanced disease.