Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT06667700
PHASE3

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

Sponsor: Merck Sharp & Dohme LLC

View on ClinicalTrials.gov

Summary

Researchers are looking for other ways to prevent severe illness from COVID-19. COVID-19 is a virus that most often causes mild flu or cold-like symptoms. However, people with certain health conditions or other factors have a high risk (chance) of getting severely ill from COVID-19, which can require a hospital stay or lead to death. Some people who are high risk for severe illness may be unable to take certain treatments for COVID-19 because they are not available to them, or they take other medicines that may react with a treatment and cause an unwanted effect. Molnupiravir (MK-4482) is a study medicine designed to stop the COVID-19 virus from copying itself in the body (multiplying). The goal of this study is to learn if molnupiravir prevents severe illness from COVID-19 more than placebo in people who are high risk.

Official title: A Phase 3, Randomized, Placebo-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy and Safety of Molnupiravir (MK-4482) in Non-Hospitalized Adults With COVID-19 at High Risk for Disease Progression

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

3082

Start Date

2024-12-02

Completion Date

2031-01-26

Last Updated

2026-04-03

Healthy Volunteers

No

Interventions

DRUG

Molnupiravir

Molnupiravir administered orally as two 400 mg film-coated tablets every 12 hours for 5 days (a total of 10 consecutive doses)

DRUG

Placebo

Molnupiravir-matching placebo administered orally as two film-coated tablets every 12 hours for 5 days (a total of 10 consecutive doses)

Locations (218)

Cullman Clinical Trials ( Site 3813)

Cullman, Alabama, United States

Helios Clinical Research ( Site 3826)

Paradise Valley, Arizona, United States

Absolute Clinical Research ( Site 3709)

Phoenix, Arizona, United States

Clinica de Salud del Valle de Salinas ( Site 3825)

Castroville, California, United States

Ascada Health PC dba Ascada Research ( Site 3750)

Fullerton, California, United States

Pacific Clinical Studies ( Site 3827)

Los Alamitos, California, United States

Valley Clinical Trials, Inc. ( Site 3707)

Northridge, California, United States

FOMAT Medical Research ( Site 3720)

Oxnard, California, United States

Paradigm Clinical Research, LLC ( Site 3785)

San Diego, California, United States

Optimus Medical ( Site 3817)

San Francisco, California, United States

Millennium Clinical Trials ( Site 3758)

Westlake Village, California, United States

Paradigm Clinical Research Centers, Inc ( Site 3718)

Wheat Ridge, Colorado, United States

Encore Medical Research of Boynton Beach ( Site 3701)

Boynton Beach, Florida, United States

Prestige Clinical Research Center ( Site 3722)

Coral Gables, Florida, United States

Indago Research & Health Center, Inc ( Site 3714)

Hialeah, Florida, United States

Prestige Clinical Research ( Site 3830)

Homestead, Florida, United States

Accel Research Sites Network - St. Pete-Largo Clinical Research Unit ( Site 3779)

Largo, Florida, United States

Clinical Site Partners, LLC dba Flourish Research ( Site 3717)

Leesburg, Florida, United States

Advanced Pulmonary Research Institute ( Site 3781)

Loxahatchee Groves, Florida, United States

Southern Clinical Research ( Site 3773)

Miami, Florida, United States

Florida Pharmaceutical Research and Associates ( Site 3763)

Miami, Florida, United States

Bio-Medical Research LLC ( Site 3804)

Miami, Florida, United States

Bright Research Center ( Site 3746)

Miami, Florida, United States

Miami Clinical Research ( Site 3729)

Miami, Florida, United States

Reed Medical Research ( Site 3761)

Miami, Florida, United States

Palm Springs Community Health Center ( Site 3757)

Miami Lakes, Florida, United States

Panax Clinical Research ( Site 3803)

Miami Lakes, Florida, United States

Combined Research Orlando Phase I-IV ( Site 3797)

Orlando, Florida, United States

CDC Research Institute ( Site 3716)

Port Saint Lucie, Florida, United States

New Tampa Health ( Site 3764)

Tampa, Florida, United States

Clinical Research Trials of Florida ( Site 3703)

Tampa, Florida, United States

Precision Research Center ( Site 3704)

Tampa, Florida, United States

Encore Medical Research - Weston ( Site 3708)

Weston, Florida, United States

Balanced Life Health Care Solutions/SKYCRNG ( Site 3713)

Lawrenceville, Georgia, United States

Renew Health Clinical Research ( Site 3760)

Snellville, Georgia, United States

Rophe Adult and Pediatric Medicine/SKYCRNG ( Site 3816)

Union City, Georgia, United States

Paradigm Clinical Research - Boise ( Site 3841)

Boise, Idaho, United States

Rush University Medical Center ( Site 3748)

Chicago, Illinois, United States

Duly Health and Care ( Site 3799)

Lombard, Illinois, United States

University of Louisville School of Medicine ( Site 3706)

Louisville, Kentucky, United States

Barnum Medical Research ( Site 3828)

Natchitoches, Louisiana, United States

Annapolis Internal Medicine - CCT Research ( Site 3700)

Annapolis, Maryland, United States

Kur Research - Columbia Medical ( Site 3767)

Columbia, Maryland, United States

Revival Research Institute, LLC ( Site 3835)

Dearborn, Michigan, United States

Michigan Center of Medical Research (MICHMER) ( Site 3734)

Farmington Hills, Michigan, United States

Henry Ford St John TM Center for Infectious Disease Research ( Site 3766)

Grosse Pointe Woods, Michigan, United States

Mankato Clinic ( Site 3842)

Mankato, Minnesota, United States

Prime Health and Wellness/SKYCRNG ( Site 3726)

Fayette, Mississippi, United States

SKY Integrative Medical Center/SKYCRNG ( Site 3740)

Ridgeland, Mississippi, United States

Nevada Health Centers ( Site 3840)

Carson City, Nevada, United States

WR-CRCN, LLC ( Site 3818)

Las Vegas, Nevada, United States

Saint Michael's Medical Center ( Site 3808)

Newark, New Jersey, United States

Holy Name Medical Center ( Site 3807)

Teaneck, New Jersey, United States

Weill Cornell Medical College ( Site 3814)

New York, New York, United States

Prime Global Research ( Site 3731)

The Bronx, New York, United States

OnSite Clinical Solutions ( Site 3784)

Charlotte, North Carolina, United States

Monroe Biomedical Research ( Site 3732)

Monroe, North Carolina, United States

IMA Clinical Research Mount Airy ( Site 3745)

Mount Airy, North Carolina, United States

Research Innovations, LLC ( Site 3712)

Beavercreek, Ohio, United States

Midlands Neurology & Pain Associates ( Site 3751)

Columbia, South Carolina, United States

Helios Clinical Research - JAC ( Site 3833)

Jackson, Tennessee, United States

Javara - Privia Medical Group Gulf Coast - The Woodlands HWH ( Site 3837)

Conroe, Texas, United States

South Texas Clinical Research ( Site 3815)

Corpus Christi, Texas, United States

Care United Research, LLC ( Site 3747)

Forney, Texas, United States

Houston Methodist Hospital ( Site 3800)

Houston, Texas, United States

MD Anderson ( Site 3843)

Houston, Texas, United States

Andres Garcia Zuniga, M.D., P.A. ( Site 3782)

Laredo, Texas, United States

LinQ Research ( Site 3824)

Pearland, Texas, United States

Crossroads Clinical Research-Family Practice ( Site 3739)

Victoria, Texas, United States

Velocity Clinical Research - Hampton ( Site 3744)

Hampton, Virginia, United States

Eastside Research Associates ( Site 3727)

Redmond, Washington, United States

CEMIC ( Site 0101)

Buenos Aires., Buenos Aires, Argentina

Hospital Italiano de Buenos Aires ( Site 0107)

Ciudad Autonoma de Buenos Aires., Buenos Aires, Argentina

Instituto de Investigaciones Clinicas Mar del Plata ( Site 0111)

Mar del Plata, Buenos Aires, Argentina

Nefra Medical Care - Moron ( Site 0109)

Morón, Buenos Aires, Argentina

Hospital Felicio Rocho (HFR) - Nucleo de Ciencias da Saude ( Site 0402)

Belo Horizonte, Minas Gerais, Brazil

Centro de Pesquisa Sao Lucas ( Site 0401)

Campinas, São Paulo, Brazil

Centro de Pesquisa Clinica Institucional do HCFMUSP - CPCi ( Site 0403)

São Paulo, Brazil

Medical Center Asclepius ( Site 0506)

Velingrad, Pazardzhik, Bulgaria

Medical Center Zdrave 1 ( Site 0509)

Kozloduy, Vratsa, Bulgaria

Medconsult Pleven - Lovech ( Site 0501)

Lovech, Bulgaria

Medical Center Hera ( Site 0507)

Montana, Bulgaria

MHAT "Dr. Stamen Iliev" Montana-Department of Pulmonology ( Site 0504)

Montana, Bulgaria

Medconsult Pleven ( Site 0503)

Pleven, Bulgaria

DKC V - Plovdiv ( Site 0508)

Plovdiv, Bulgaria

SHATPPD Dr. Dimitar Gramatikov - Ruse EOOD ( Site 0502)

Rousse, Bulgaria

Diagnostic Consultative Center 22 - Sofia ( Site 0500)

Sofia, Bulgaria

Medical Center Hera EOOD ( Site 0505)

Sofia, Bulgaria

IPS SURA San Diego ( Site 0806)

Medellín, Antioquia, Colombia

IPS Centro Científico Asistencial S.A.S ( Site 0800)

Barranquilla, Atlántico, Colombia

Clinica Colsanitas - Sede Reina Sofia ( Site 0807)

Bogotá, Bogota D.C., Colombia

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 0804)

Bogotá, Bogota D.C., Colombia

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0801)

Valledupar, Cesar Department, Colombia

IMAT S.A.S ( Site 0805)

Montería, Departamento de Córdoba, Colombia

Fundación Valle del Lili ( Site 0803)

Cali, Valle del Cauca Department, Colombia

MeVac - Meilahti Vaccine Research Center ( Site 1200)

Helsinki, Uusimaa, Finland

Centre Hospitalier Universitaire Dijon Bourgogne - Hôpital F-Centre d'Investigation Clinique - Plur ( Site 1301)

Dijon, Bourgogne-Franche-Comté, France

CHU de Saint-Etienne ( Site 1302)

Saint Priest En Jarez, Pays de la Loire Region, France

centre hospitalier lyon sud ( Site 1303)

Pierre-Bénite, Rhone, France

Pitie Salpetriere University Hospital-Infectious Disease - Tropical Diseases ( Site 1300)

Paris, Île-de-France Region, France

Clinic Health - Batumi ( Site 1405)

Batumi, Adjara, Georgia

Family Medical Regional Center ( Site 1404)

Batumi, Adjara, Georgia

LTD High Technology Hospital Medcenter ( Site 1408)

Batumi, Adjara, Georgia

University Clinic of Innovative Medicine ( Site 1400)

Batumi, Adjara, Georgia

Caucasus Medical Centre ( Site 1406)

Tbilisi, Adjara, Georgia

"Georgian Clinics" JSC ( Site 1410)

Zugdidi, Samegrelo and Zemo Svaneti, Georgia

New Hospitals ( Site 1409)

Tbilisi, Georgia

Curatio Clinic - Main Location ( Site 1401)

Tbilisi, Georgia

TUM Klinikum ( Site 1502)

Munich, Bavaria, Germany

Universitätsklinikum Frankfurt Goethe-Universität ( Site 1503)

Frankfurt am Main, Hesse, Germany

Universitaetsklinikum Koeln ( Site 1505)

Cologne, North Rhine-Westphalia, Germany

Campus Charite Mitte Nephrologie und Internistische Intensivmedizin ( Site 1501)

Berlin, State of Berlin, Germany

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1904)

Bologna, Italy

Ospedale San Martino ( Site 1900)

Genova, Italy

ASST Fatebenefratelli Sacco ( Site 1901)

Milan, Italy

AOU Pisana- Ospedale Cisanello ( Site 1905)

Pisa, Italy

National Hospital Organization Shimoshizu National Hospital ( Site 2007)

Yotsukaidō, Chiba, Japan

Tsuchiura Beryl Clinic ( Site 2009)

Tsuchiura, Ibaraki, Japan

National Hospital Organization Tokyo National Hospital ( Site 2003)

Kiyose, Tokyo, Japan

Sekino Hospital ( Site 2016)

Toshimaku, Tokyo, Japan

National Hospital Organization Kyushu Medical Center ( Site 2006)

Fukuoka, Japan

Kumamoto Chuo Hospital ( Site 2002)

Kumamoto, Japan

Morales Vargas Centro de Investigacion ( Site 2206)

León, Guanajuato, Mexico

CIO - Centro de Inmuno-Oncología de Occidente ( Site 2207)

Guadalajara, Jalisco, Mexico

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran-Departamento de Infectología ( Site 2203)

Mexico City, Mexico City, Mexico

Instituto Nacional de Salud Publica ( Site 2205)

Cuernavaca, Morelos, Mexico

Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Infectologia ( Site 2204)

Monterrey, Nuevo León, Mexico

Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan ( Site 2202)

Mérida, Yucatán, Mexico

ICARO Investigaciones en Medicina ( Site 2200)

Chihuahua City, Mexico

Arké SMO S.A de C.V-ARKE SMO S.A. de C.V. ( Site 2210)

Veracruz, Mexico

CGM Research Trust ( Site 2307)

Christchurch, Canterbury, New Zealand

Pacific Clinical Research Network - Tasman ( Site 2304)

Nelson, Tasman District, New Zealand

Lakeland Clinical Trials Waikato ( Site 2302)

Nawton, Waikato Region, New Zealand

Lakeland Clinical Trials Wellington ( Site 2303)

Upper Hutt, Wellington Region, New Zealand

Pacific Clinical Research Network West Auckland ( Site 2301)

Auckland, New Zealand

Optimal Clinical Trials North ( Site 2308)

Auckland, New Zealand

Silverdale Medical Limited ( Site 2305)

Auckland, New Zealand

Optimal Clinical Trials ( Site 2306)

Auckland, New Zealand

Asociación Civil Selva Amazónica ( Site 2405)

Iquitos, Loreto, Peru

Via Libre ( Site 2409)

Lima, Peru

Clinica Ricardo Palma-Centro de Investigacion de Enfermedades Respiratorias Thorax ( Site 2404)

Lima, Peru

Health Index Multispeciality Clinic ( Site 2501)

Bacoor, Cavite, Philippines

Ospital Ng Makati ( Site 2505)

Makati City, National Capital Region, Philippines

GreenCity Medical Center ( Site 2503)

San Fernando City, Pampanga, Philippines

PL Certus ( Site 2613)

Poznan, Greater Poland Voivodeship, Poland

In-Vivo Bydgoszcz ( Site 2601)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

NZOZ GynCentrum - Oddział Kraków ( Site 2609)

Krakow, Lesser Poland Voivodeship, Poland

Penta Hospitals Przychodnie Wrocław Wejherowska ( Site 2611)

Wroclaw, Lower Silesian Voivodeship, Poland

NZOZ GynCentrum - Oddział Bielsko-Biała ( Site 2602)

Bielsko-Biala, Silesian Voivodeship, Poland

Clinical Medical Research ( Site 2604)

Katowice, Silesian Voivodeship, Poland

Holsamed ( Site 2603)

Katowice, Silesian Voivodeship, Poland

Investigadores del Este LLC ( Site 4001)

Humacao, Puerto Rico

Miralles Clinical Research LLC ( Site 4004)

San Juan, Puerto Rico

MV HEALTH SERVICES LLC ( Site 4003)

San Juan, Puerto Rico

Spitalul Clinic de Boli Infecțioase și Tropicale Victor Babeș ( Site 2701)

Bucharest, București, Romania

Spitalul Clinic De Urgenta Prof Dr Agrippa Ionescu ( Site 2705)

Baloteşti, Ilfov, Romania

Centrul Medical SANA ( Site 2704)

Bucharest, Romania

National Institute for Infectious Diseases Prof. Dr. Matei Bals ( Site 2706)

Bucharest, Romania

Spitalul Clinic de Boli Infecțioase ( Site 2703)

Cluj-Napoca, Romania

Spitalul Clinic de Boli Infecțioase ( Site 2702)

Constanța, Romania

Wonju Severance Christian Hospital-Internal Medicine ( Site 3009)

Wŏnju, Kang-won-do, South Korea

Chonnam National University Hospital-Infectious Diseases ( Site 3008)

Gwangju, Kwangju-Kwangyokshi, South Korea

Korea University Ansan Hospital ( Site 3007)

Ansan-si, Kyonggi-do, South Korea

Gyeongsang National University Hospital ( Site 3005)

Jinju, Kyongsangnam-do, South Korea

Pusan National University Hospital-Internal Medicine ( Site 3010)

Pusan, Pusan-Kwangyokshi, South Korea

Kyungpook National University Chilgok Hospital-Division of Infectious Diseases ( Site 3002)

Deagu, Taegu-Kwangyokshi, South Korea

Korea University Anam Hospital ( Site 3001)

Seoul, South Korea

Hallym University Kangnam Sacred Heart Hospital-Internal Medicine ( Site 3003)

Seoul, South Korea

Korea University Guro Hospital ( Site 3006)

Seoul, South Korea

Hospital General Universitario de Elche-Infectius Disease ( Site 3105)

Elche, Alicante, Spain

Hospital Germans Trias i Pujol ( Site 3101)

Badalona, Barcelona, Spain

EAP Osona Sud - Alt Congost S.L.P ( Site 3107)

Centelles, Barcelona, Spain

Hospital Universitari Vall d'Hebron ( Site 3102)

Barcelona, Catalonia, Spain

Hospital Universitario de A Coruña ( Site 3112)

A Coruña, Galicia, Spain

Hospital Santa Lucia-Medicina Infecciosas ( Site 3106)

Cartagena, Murcia, Spain

EAP Sardenya ( Site 3109)

Barcelona, Spain

Hospital Universitario Infanta Leonor ( Site 3110)

Madrid, Spain

HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO ( Site 3100)

Seville, Spain

Kaohsiung Medical University Chung-Ho Memorial Hospital ( Site 3306)

Kaoshiung, Kaohsiung, Taiwan

Taoyuan General Hospital ( Site 3300)

Taoyuan, Taoyuan, Taiwan

Kaohsiung Veterans General Hospital ( Site 3307)

Kaohsiung City, Taiwan

Taipei Medical University - Shuang Ho Hospital ( Site 3308)

New Taipei City, Taiwan

Taichung Veterans General Hospital ( Site 3305)

Taichung, Taiwan

National Taiwan University Hospital ( Site 3301)

Taipei, Taiwan

Tri-Service General Hospital ( Site 3304)

Taipei, Taiwan

Taipei Municipal Wangfang Hospital ( Site 3309)

Taipei, Taiwan

Chang Gung Memorial Hospital - Linkou Branch ( Site 3303)

Taoyuan District, Taiwan

Faculty of Medicine Siriraj Hospital-Department of Medicine ( Site 3401)

Bangkok, Bangkok, Thailand

HIV Netherlands Australia Thailand Research Collaboration ( Site 3402)

Pathumwan, Bangkok, Thailand

EUROMEDCLINIC ( Site 3517)

Cherkasy, Cherkasy Oblast, Ukraine

MUNICIPAL NON-PROFIT ENTERPRISE CENTRAL CITY CLINICAL HOSPITAL OF CHERNIVTSI CITY COUNCIL ( Site 3513)

Chernivtsi, Chernihiv Oblast, Ukraine

Clinical medical and diagnostic center Limited Liability Company "Simedgroup" ( Site 3524)

Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine

Regional Phthisiology and Pulmonology Center ( Site 3523)

Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine

Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 3537)

Kropyvnytskyi, Kirovohrad Oblast, Ukraine

Limited Liability Company Ukrainian Center of Tomotherapy-Clinical Trials Department ( Site 3512)

Kropyvnytskyi, Kirovohrad Oblast, Ukraine

Medical Center "Harmoniya Krasy" ( Site 3545)

Kyiv, Kyivska Oblast, Ukraine

Edelweiss Medics ( Site 3503)

Kyiv, Kyivska Oblast, Ukraine

Communal Non-Profit Enterprise "Kyiv City Clinical Hospital #1"-Department of Clinical Research ( Site 3514)

Kyiv, Kyivska Oblast, Ukraine

Medbud Clinic-Treatment prevention unit ( Site 3506)

Kyiv, Kyivska Oblast, Ukraine

Medical Center of Limited ( Site 3546)

Kyiv, Kyivska Oblast, Ukraine

Center of Family Medicine Plus ( Site 3502)

Kyiv, Kyivska Oblast, Ukraine

Polyclinic of Communal 4th city clinical hospital ( Site 3501)

Lviv, Lviv Oblast, Ukraine

Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 3525)

Lviv, Lviv Oblast, Ukraine

University clinic of the National Pirogov Memorial Medical University ( Site 3547)

Vinnytsia, Vinnytsia Oblast, Ukraine

Clinic of Pyrohov National Medical University of Vinnytsia ( Site 3528)

Vinnytsia, Vinnytsia Oblast, Ukraine

Municipal Enterprise "Volyn Regional Clinical Hospital" of Volyn Regional Council ( Site 3530)

Lutsk, Volyn Oblast, Ukraine

Uzhhorod Municipal Multidisciplinary Clinical Hospital of Uzhhorod City Council ( Site 3538)

Uzhhorod, Zakarpattia Oblast, Ukraine

Medlight Clinic ( Site 3548)

Kyiv, Ukraine

Kyiv Railway Clinical Hospital No.2 of Branch Health Center -Center of Clinical Trials ( Site 3549)

Kyiv, Ukraine

Whiteladies Medical Group ( Site 3611)

Bristol, Bristol, City of, United Kingdom

Royal Devon & Exeter Hospital ( Site 3604)

Exeter, England, United Kingdom

Royal Victoria Infirmary ( Site 3608)

Newcastle, Newcastle Upon Tyne, United Kingdom

Norwich Practices Health Centre ( Site 3605)

Norwich, Norfolk, United Kingdom

Oak Street Medical Practice ( Site 3612)

Norwich, Norfolk, United Kingdom

Lakeside Surgery ( Site 3600)

Northamptonshire, Northamptonshire, United Kingdom

Bicester Health Centre ( Site 3609)

Bicester, Oxfordshire, United Kingdom

Banbury Cross Health Centre ( Site 3610)

Oxford, Oxfordshire, United Kingdom

Buttercross Health Centre ( Site 3606)

Somerset, Somerset, United Kingdom