Clinical Research Directory

Inclusion Criteria: 1. Over 18 and below 40 years of age 2. Good general health 3. Able to give informed consent Exclusion Criteria: 1. Any major medical or psychiatric condition (e.g. heart disease, diabetes, autoimmune disorders, infectious diseases, major depressive disorder), any chronic pain condition, any respiratory problems, any acute pain at time of study 2. Inability to follow study instructions, e.g. due to language problems 3. Pregnancy (female participants will be asked if pregnancy could be possible) 4. Increased alcohol (\>2 (for women)/4 (for men) standard glasses per day or \>5 (for women)/4 (for men) glasses at least once a month within a few hours) or caffeine consumption (≥ 400mg per day) 5. Consumption of alcohol, drugs, analgesics within the last 24 h 6. Consumption of more than 100 mg of caffeine within the last 8 h 7. Scar tissue or generally reduced sensitivity in the designated testing site areas 8. Shoe size \< 38 (if experiment is conducted at the feet) 9. History of cardiovascular disease or carotid artery disease 10. Medication or Substances inferring with the autonomic nervous system or with pain sensitivity (e.g. Benzodiazepines, Nicotine)